This Zenodo deposit contains a publicly available description of the Dataset: Title: "iSCORE-PD: NGS genotyping and zygosity testing of isogenic hESC clones". Description: Targeted DNA sequencing data for the iSCORE-PD isogenic hESC clone collection, encompassing three complementary analyses: (1) NGS genotyping of 53 m...
Oriol Busquets, Hanqin Li, Khaja Mohieddin Syed et al.· Zenodo (CERN European Organi...· 0 citations
[Purpose] A key pathological hallmark of amyotrophic lateral sclerosis (ALS) is transactive response DNA-binding protein 43 (TDP-43, encoded by TARDBP) proteinopathy. Mutations in TARDBP and cellular stress can drive nuclear clearance and cytoplasmic aggregation of TDP-43. TDP-43 is an essential nuclear RNA-binding pro...
This Zenodo deposit contains a publicly available description of the Dataset: Title: "iSCORE-PD: NGS genotyping and zygosity testing of isogenic hESC clones". Description: Targeted DNA sequencing data for the iSCORE-PD isogenic hESC clone collection, encompassing three complementary analyses: (1) NGS genotyping of 53 m...
Oriol Busquets, Hanqin Li, Khaja Mohieddin Syed et al.· Zenodo (CERN European Organi...· 0 citations
An effective method for eliminating HLA class I expression in HEK293T cells via simultaneous CRISPR/Cas9 editing of the HLA‑A, HLA‑B, and HLA‑C genes using a single guide RNA is described.
U. Boyarskikh, A. Serych, E. Khrapov et al.· Bulletin of experimental bio...· 0 citations
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This study engineer compact photoswitchable Cas12f (psCas12f) proteins that are co-deliverable with their single guide RNA (sgRNA) in a single AAV particle, enabling precise spatiotemporal control in vivo.
Daesun Song, Marigold G. Malinao, Xiang Wu et al.· Cell· 0 citations
A unifying innate-sensing architecture for nucleic-acid therapeutics is defined and it is established that reactogenicity is not required for effective vaccination or gene delivery, enabling a broadly applicable strategy to widen the safety window of mRNA medicines, viral vectors, and in vivo genome editing.
D. Lainšček, Š. Malenšek, V. Forstnerič et al.· Molecular Therapy· 0 citations
This review introduces 'translational checkpoints' as a synthesized working framework for overcoming resistance by targeting RNA-binding proteins (RBPs) that govern rapid protein synthesis in tumour and immune cells and establishes a four-subtype diagnostic stratification system and five actionable therapeutic strategi...
Peng Liu, Jing-Jing Liu· Critical reviews in oncology...· 0 citations
DOPA decarboxylase (DDC) is a key enzyme that connects melanin production and innate immunity in insects, yet its regulatory network in major lepidopteran pests remains poorly understood. We combined CRISPR/Cas9 gene editing with multi-omics analysis to explore DDC's role in immune responses in the invasive pest Spodop...
Ze-Yuan Zhang, Shang-Huan Huang, Shen-Lei Li et al.· Insect Science· 0 citations
The ecology- and genomics-driven evolution of this economically important virus and strategies targeting streak resistance in maize are discussed, and a five-cardinal agenda for future research covering layered surveillance-supported host resistance, evolutionary surveillance, agro-ecological alignment of breeding, esc...
K. A. Oyeniran, Temilola Aina, Lara Donaldson· Virus Research· 0 citations
Further advancements in CRISPR technology such as high-fidelity CRISPR and new systems Cas12 and Cas13 which increases efficiency of editing and opens more opportunities are discussed which increases efficiency of editing and opens more opportunities.
S. Acharyya, B. Behera, Ritika Pradhan et al.· Nucleosides, Nucleotides & N...· 0 citations
A testable model wherein environmental triggers and host hormone balance converge temperature-regulated virulence gene expression to govern the endophyte-to-necrotroph transition is proposed.
S. AbuQamar, Arshiya Akbar, Gouthaman P. Purayil et al.· Molecular Plant-Microbe Inte...· 0 citations
Xenotransplantation using genetically engineered porcine organs has emerged as a transformative strategy to address the critical organ shortage crisis in Asia, where low deceased donation rates and high disease burden create a persistent supply-demand gap. This review examines the Asian perspective on xenotransplantati...
Kun Wang, Xia-Yu Lei, Tao Li et al.· Clinical transplantation and...· 0 citations
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
