A new protoplast-based platform enables transient transformation and proof-of-concept CRISPR/Cas12a-mediated genome editing in European beech, a key but recalcitrant forest tree species.
Virginia Zahn, Alice-Jeannine Sievers, B. Kersten et al.· Communications Biology· 0 citations
A potential combination between gene therapy approaches and existing modulators to improve treatment eligibility, safety, and efficacy for cystic fibrosis patients is discussed.
A review of studies in which the creation of a CRISPR-Cas9 animal model has been used to find genetic drivers and develop therapies across 4 CVD domains shows the vast range of gene editing applications and the value of models that parallel human genetic pathophysiology for specific disease processes.
J. Longmire, Harrison Smith-Jaoudi, Eesha Balar et al.· Georgetown Medical Review· 0 citations
It is demonstrated that viperin plays a central role in coordinating antiviral responses in rainbow trout macrophages and is essential for proper activation of classical IFN–ISG pathways.
Mariana Vaz, A. Florea, G. E. Themudo et al.· Scientific Reports· 0 citations
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Preliminary evidence indicates that targeted editing of OsASY offers a promising strategy to reduce grain Cd content without adversely affecting major agronomic traits or yield, highlighting its potential as a molecular target for breeding low-Cd-accumulating rice varieties.
Chun-Yan Tu, Wei Huang, Dao-Bo Wang et al.· Journal of Hazardous Materia...· 0 citations
By explaining how a single amino acid change produces a hypomorphic PIEZO2 allele, the findings broaden the clinical spectrum of PIEZO2 disorders and offer structural insight into mechanotransduction.
Alec R. Nickolls, Eric M. Mulhall, Daniel J. Orlin et al.· Neuron· 0 citations
Overall, the existing findings support TAAR1 as a therapeutic target for treatment of substance use disorders, however, translating these findings into effective human pharmacotherapies requires navigating ligand-specific effects and pharmacokinetic demands and defining the role of human TAAR1 genetic diversity in ther...
Samantha M. Rios, S. Shabani, T. J. Phillips· Handbook of Experimental Pha...· 0 citations
This paper focuses on the heterologous expression of functional genes via transgenic technology and explores the potential of gene editing technologies for heavy metal remediation, thereby offering a reference for future environmental remediation efforts and the development of related processes.
Kaiyang Zheng, Yeting Weng, Ran Zhao· Sheng wu gong cheng xue bao...· 0 citations
Millets are a diverse group of underutilized C4 cereals with high photosynthetic efficiency and resilience to marginal environments; however, the functional and nutritional potential of their starches remains largely untapped. This review provided a systematic summary of current research in millet starches, covering ex...
Raheela Amin, Huabing Lu, Jing Yu et al.· Comprehensive Reviews in Foo...· 0 citations
Rice is one of the most significant crops consumed daily by individuals. Enhancing and biofortifying rice to augment its nutritional value is a promising strategy for improving public health and tackling the widespread issue of micronutrient deficiencies. This study primarily attempted to evaluate the developed Cas9-fr...
A novel embryonic axis-based regeneration system enables rapid shoot recovery, rooting, and biolistic gene delivery in cacao, substantially shortening the timeline for plant transformation.
Suzam L. da S. Pereira, Grazielle da M. Alcântara, Gláucia C. B. Silva et al.· Plant Cell Tissue and Organ...· 0 citations
The identification and characterization of an activating point mutation of SHP2 (encoded by the PTPN11 gene), SHP2-F71L, in UKE1 cells is reported, suggesting activating PTPN11 mutations have the potential to desensitize the effects of JAK2 inhibition therapy in patients undergoing therapy and may be dependent on unkno...
Tegan M. Rowsell, G. Pandey, Lucia Mazzacurati et al.· bioRxiv· 0 citations
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.