AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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1,434 papers
It is confirmed that multi-targeting sgRNAs disproportionately impair cell fitness and that sgRNAs aligning to more than one location with a single mismatch can also reduce fitness, although to a lesser extent.
A scarless conditional sgRNA platform that combines Cre-loxP recombination with endogenous RNA processing to restore the native sgRNA architecture following induction is developed that preserves guide integrity and should be readily adaptable to time-resolved functional genomics and pooled screening applications.
The combination knockout of CCR5, MOGS, and viral sequences profoundly reduces HIV-1 replication in an ex vivo cellular model, that is, HIV-1-infected peripheral blood mononuclear human cells, thus offering a pathway to launch further preclinical studies.
This review synthesises the fundamental principles and limitations of multiple gene-editing technologies, with a particular emphasis on CRISPR systems (Cas9, Cas12, and Cas13), in the specific context of woody perennial biology, and highlights how synergising CRISPR technologies with multi-omics, genomic selection, and...
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Findings reveal that FA9 interacts with VAP to promote lipid droplet biogenesis and lipid transport, thereby driving fatty acid accumulation in soybean seeds.
ProphDR is an interpretable deep learning framework that integrates multiomics data and drug structural information using a hierarchical attention mechanism, and generates biologically interpretable attention maps that highlight key pharmacophores and resistance-related genes consistent with established mechanisms in N...
The present study addresses optimization of in-vitro regeneration via direct organogenesis and Agrobacterium-mediated genetic transformation, enabling efficient multiplex CRISPR/Cas9-based genome editing of the phytoene desaturase (PsPDS) gene in pea. Pea (Pisum sativum L.) is an important legume crop valued for food,...
Rice (Oryza sativa L.) is highly vulnerable to drought during the reproductive phase, with yield losses exceeding 50% due to spikelet sterility, pollen abortion, and impaired grain filling. Progress through conventional breeding has been constrained by the polygenic nature of drought tolerance and by strong genotype ×...
Overall, despite existing challenges, neoantigen-targeted immunotherapies hold promise for advancing precision oncology and improving patient outcomes.
It is demonstrated that porcine expanded potential stem cells, derived from preimplantation embryos, provide a robust and versatile platform for generating donor cells for xenotransplantation and for functionally evaluating genetic modifications, thereby advancing the prospects of xenotransplantation.
This review summarizes the trajectory of iPSC reprogramming technologies and identifies the core “translational triltrilas”, namely, the inherent tradeoffs between security, homogeneity, and scalability, and proposes a comprehensive strategy to overcome these bottlenecks.
A charge-altering releasable transporter (CART) that delivers RNA selectively to the corneal endothelium, a non-regenerative cell layer whose dysfunction underlies several blinding conditions and establishes CARTs as a platform for non-viral gene delivery to the eye, with the potential to treat corneal dystrophies and...
GPT-Lab
· gpt-lab.eu
Oct 8, 2026
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
A Blog post by Ai2 on Hugging Face
A Blog post by ServiceNow-AI on Hugging Face
“InstructMesh” can generate designs for everyday objects that are easy to edit and fabricate for both experts and newcomers to 3D modeling.
Proof of concept for watermarking AI-generated proteins while preserving biological function.
Algorithms & Theory
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