gene editing

Intranasal CRISPR lipid nanoparticles targeting MAPK9 attenuate neuroinflammation after traumatic brain injury

It is demonstrated that intranasal delivery of Iba-1-targeted CRISPR-LNPs enables effective MAPK9 modulation in Iba-1 + myeloid cells within the injured brain and attenuates acute neuroinflammation following TBI.

Eimeria in chickens: Recent advances in host-pathogen interactions, molecular insights, and control strategies.

This review systematically synthesizes key advances over the past decade concerning host-Eimeria interactions, molecular regulatory mechanisms, and novel control strategies, while contextualizing these findings with earlier seminal discoveries.

Gene Editing Therapy Developer Scribe Therapeutics Closes $155.5M IPO.

Genome-wide Identification of CXE Gene Family in Soybean and Functional Characterization of GmCXE31 in Lipid Biosynthesis and Salt Tolerance.

This study elucidates the multifaceted roles of GmCXE31 in coordinating soybean salt tolerance, lipid metabolism and agronomic traits, providing theoretical and genetic resources for salt-tolerant and high-quality soybean molecular breeding.

Programmable Domestication: CRISPR, Pan‐Genomics and System Level Engineering for Next‐Generation Crops

ABSTRACT Global agriculture is increasingly challenged by climate instability, genetic erosion, emerging pathogens and rising food demands, exposing the limitations of conventional breeding and traditional domestication strategies. Recent advances in CRISPR‐based genome editing, pangenomic, synthetic biology, artificia...

Immune cell development from human pluripotent stem cells.

This review summarizes research with a focus on clinical translation of iPSC-derived immune cells, as well as highlights continued challenges and prospects of this field.

Mitochondrial DNA A3243G variant-associated MELAS: Recent advances in clinical trials, therapeutic interventions, and disease-modifying strategies.

The therapeutic landscape for MELAS is evolving from symptomatic care toward mechanism-based disease modification, led by taurine as the first regulatory-approved disease-modifying therapy and complemented by late-stage small molecules and mitochondrial genome-editing technologies.

Beyond Mixed Utilization: Fractionation, Functional Divergence, and Precision Applications of Soybean 7S and 11S Globulins.

Soybean β-conglycinin (7S) and glycinin (11S) differ markedly in their structure, physicochemical properties, and bioactivity; however, industrial practice still treats them as a mixed ingredient, obscuring their differentiated functional potential. This review critically evaluates fractionation technologies through th...

Multi-species Comparative Analysis Identifies Conserved Enhancers for Improving Casein Expression via Gene Editing.

This research introduces a novel strategy to augment casein expression in ruminants, providing a significant theoretical foundation and technical support for the precision breeding of high-casein dairy cows and goats.

ZBP1 in Neuroinflammation and Neurodegeneration: Z-Nucleic-Acid Sensing, RHIM Signalling and Therapeutic Targeting

Competition with adenosine deaminase acting on RNA 1 (ADAR1), melanoma differentiation-associated protein 5 (MDA5), double-stranded RNA-dependent protein kinase (PKR), the cyclic guanosine monophosphate–adenosine monophosphate–adenosine monophosphate synthase–stimulator of interferon genes (cGAS–STING) pathway, and oth...

Application of Lipid Nanoparticles (LNPs) in Nucleic Acid Delivery and Precision Medicine

This article systematically reviews the component design, structural engineering, preparation technologies, clinical applications, and future development directions of LNPs, aiming to provide theoretical support and practical guidance for vector development in the era of precision medicine.

Loss-of-function of StFKF1 delays flowering and tuberization under long-day conditions in potato

Evidence is provided suggesting that StFKF1 influences the timing of flowering and tuber initiation, as well as the expression patterns of key regulatory genes, under long-day conditions, thereby contributing to a theoretical foundation for understanding developmental transitions in this specific environmental context.