Open access
Transmembrane glycoprotein BSG serves a dual role as a prognostic and immunological modulator in the tumor microenvironment of lung adenocarcinoma
Xiao-Fei Zhang
Q. Peng
Wen-Lang Zhu
Jian-Guo Zhang
Zheng-Fei Zhu
Kuai-Le Zhao
Pei-Yi Liu
Wei-Xin Zhao
Medicine
TL;DR
Experimental validation confirms BSG's protein expression and prognostic relevance in LUAD and indicates that high BSG expression is an independent prognostic factor for poor survival in LUAD.
Abstract
Highlights • BSG is significantly upregulated in lung adenocarcinoma (LUAD) tissues.• High BSG expression is an independent prognostic factor for poor survival in LUAD.• BSG expression negatively correlates with the infiltration of key anti-tumor immune cells.• BSG is closely associated with immune checkpoint molecules and chemokine networks.• Experimental validation confirms BSG's protein expression and prognostic relevance in LUAD.