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Integrated single-cell and bulk transcriptomic analysis reveals an epithelial cell-derived prognostic and immunotherapeutic signature with ADAM12 as a key functional regulator in non-small cell lung cancer

Hai-Lin Liu Jun-Jie Yu Yan-Tao Jiang Xiao-Fei Ma Wei Luo Shu-Yue Guo Lu-Yao Tong Yi Lu Zhen-Fa Zhang Chenguang Li Jian-Wei Qi Ting-Ting Qin

Sep 2026 · Translational Oncology · Vol 73, pp. 103028 · 0 citations · 48 references

Medicine

Abstract

Highlights • Single-cell transcriptomics reveals epithelial heterogeneity shaping NSCLC immunity.• A 101-algorithm ML framework constructs a Prognostic and Immunotherapeutic Signature.• PIS stratifies NSCLC patients by prognosis and immune checkpoint blockade response.• ADAM12 inhibition enhances anti-PD-1 efficacy in preclinical mouse models.

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