Identification of a three-gene prognostic signature associated with tumor immune characteristics in lung adenocarcinoma: A comprehensive analysis of multi-omics data

Abstract

Highlights ● Multi-omics analysis identifies a robust three-gene prognostic signature for LUAD.● The signature stratifies patients by survival and tumor immune characteristics.● High-risk tumors display proliferative programs and immunotherapy-related features.● The model predicts differential responsiveness to immune checkpoint blockade.● BRCA1 drives malignant progression and validates the biological significance of the signature.