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#gene editing

Highly efficient base editing at PCSK9 and normal human embryo development.

Stepan Jerabek Chan-Ju Jung M. Kappy Qiao-Jin Zhao Julie Sung Ning Wang Euihyun Kim Jimin Kim M. Kulmann Madeleine B. King M. J. McAndrew Meng Li Sakshi Bhatele M. Isado HongSeok Jang M. Doležal R. Prosser Shuang-Yi Xu Gue-Ho Hwang I. Pichová Jia Xu Diego Marin Jae-Sung Woo Sangsu Bae Nathan Treff Audrone Lapinaite Dieter Egli
Sep 2026 · Nature · 1 citation
Medicine

TL;DR

DNA repair outcomes at nicks and mismatches introduced by base editors at the PCSK9 and HBG loci in human embryos are evaluated, finding that unlike Cas9-induced DNA breaks, base editor-induced lesions are efficiently repaired.

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