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Author

Sakshi Bhatele

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Open access Jul 2026

Modeling immune responses to autologous and allogeneic human stem cell-derived islet grafts in vivo 2332710

While allogeneic grafts undergo strong immune infiltration and tissue remodeling, autologous stem cell-derived islet grafts remain largely protected, even in the presence of autoreactive T cells, indicating that additional stimuli may be required to trigger autoimmune β-cell targeting in vivo.

Giorgia Zanetti, Camillo Bechi Genzano, Sakshi Bhatele et al. · 0 citations
#gene editing Sep 2026

Highly efficient base editing at PCSK9 and normal human embryo development.

DNA repair outcomes at nicks and mismatches introduced by base editors at the PCSK9 and HBG loci in human embryos are evaluated, finding that unlike Cas9-induced DNA breaks, base editor-induced lesions are efficiently repaired.

Stepan Jerabek, Chan-Ju Jung, M. Kappy et al. · 1 citation

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