The findings extend the mechanistic understanding of Rab7 beyond its catalytic pocket and establish the AflRab7 C-terminal IDR as a critical regulatory element that couples vacuolar dynamics to A. flavus development and aflatoxin biosynthesis, highlighting a tractable target for mitigating fungal toxigenic potential.
Yu Wang, Chunlan Xie, Xiaoliu Ming et al.· International Journal of Bio...· 0 citations
ABSTRACT Enterovirus 2B is a highly conserved, functionally versatile, nonstructural protein. The classic viroporin model, which restricts its role to ion channel formation, cannot account for its interactions with host factors such as Bcl-2-associated X protein, interleukin enhancer-binding factor 2, and karyopherin s...
Zeng-Jun Ji, Yi-Kun Chen, Hong-Xing Shen· Virulence· 0 citations
In this proposed model, anagrelide remodels the interactome of the PDE3A-SLFN12 complex, which relocalizes and accumulates near the mRNA entry channel of the 43S pre-initiation complex, which provides important mechanistic context for how PDE3A modulators act within the cell.
S. Salmikangas, Iina Lindholm, Nasrin Sultana et al.· Molecular & Cellular Proteom...· 0 citations
It is proposed that TMEM263 can interact with and support the condensation of neutral lipids in a bilayer to promote lipid droplet formation and growth and provide a mechanistic understanding linking these phenotypes to impaired lipid droplet biology.
Katy Yalci, N. Chala, Joanna J. Moss et al.· Nature Communications· 0 citations
ABSTRACT Apicomplexan parasites are protozoan pathogens responsible for major human diseases, including toxoplasmosis, malaria, and cryptosporidiosis. Toxoplasma gondii has emerged as a model for studying cell division in tissue coccidians. Unlike higher eukaryotes that divide by binary fission, Toxoplasma replicates v...
Rajshekhar Y. Gaji, Padmaja Mandadi, D. Ali et al.· mBio· 0 citations
Using a live-cell lipid reporter, membrane order probe, and surface proteome mapping, it is shown that TMEM30A-knockout cells display robust PS externalization accompanied by faster lateral diffusion of membrane constituents and decreased plasma membrane order.
C. Gurdap, F. Ragaller, Marion Muller et al.· Journal of Cell Science· 1 citation
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