Open access
Sep 2026
A sphingomyelin-cholesterol complex regulates TLR4 activation in microglia
It is shown that LPS increases cholesterol uptake and mobilization, whereas inhibition of intracellular cholesterol trafficking or the plasma membrane-to-ER cholesterol transporter Aster attenuates inflammatory responses, establishing sphingolipid-dependent cholesterol accessibility as a key regulatory layer controllin...
C. Antón-Barros, Beatriz Villarejo-Zori, Sara Carmona-Lorenzo et al.
· bioRxiv · 0 citations