Open access
Jul 2026
SARS-CoV-2 ORF7a drives mitochondrial dysfunction via PDK4 activation and complex I inhibition.
It is demonstrated that ORF7a disrupts mitochondrial metabolism through enzymatic regulation and destabilization of the respiratory chain, highlighting mitochondria as a target of SARS-CoV-2-induced metabolic reprogramming.
Raúl Fernández-Rodríguez, Carmen M. Soto-Jiménez, Rebeca Acín-Pérez et al.
· Cell Reports · 0 citations