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Raúl Fernández-Rodríguez

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Open access Sep 2026

SARS-CoV-2 ORF8 Exploits Host miRNA Networks to Rewire Post-Transcriptional Regulation

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes several accessory proteins that modulate host cellular pathways and contribute to immune evasion and disease severity. Among them, ORF8 has emerged as a key immunomodulatory factor; however, its impact on host post-transcriptional regulatory networks...

Raúl Fernández-Rodríguez, José M. Suárez-Cárdenas, Antonio Romero-Guillén et al. · 0 citations
Open access Jul 2026

SARS-CoV-2 ORF7a drives mitochondrial dysfunction via PDK4 activation and complex I inhibition.

It is demonstrated that ORF7a disrupts mitochondrial metabolism through enzymatic regulation and destabilization of the respiratory chain, highlighting mitochondria as a target of SARS-CoV-2-induced metabolic reprogramming.

Raúl Fernández-Rodríguez, Carmen M. Soto-Jiménez, Rebeca Acín-Pérez et al. · 0 citations

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