Accelerated Biological Aging, Neurodegenerative Disease, and Mortality in Cardiovascular Disease Patients: Mediation and Modification Analysis

Comprehensive Evaluation of Atherosclerotic Cardiovascular Disease Risk Predictors Across the Pooled Cohort Equations, Predicting Risk of Cardiovascular Disease Events, and an Expanded Model

Ten‐year atherosclerotic cardiovascular disease (ASCVD) risk prediction models include the pooled cohort equations (PCE) and the Predicting Risk of Cardiovascular Disease Events (PREVENT) models. We evaluated the relative contributions of predictors in these models, along with social determinants and emerging biomarkers.

Associations of Healthy Lifestyle With All‐Cause and Cardiovascular Disease Mortality in Individuals With Cardiovascular‐Kidney‐Metabolic Syndrome: Two Prospective Cohort Studies

Cardiovascular‐kidney‐metabolic (CKM) syndrome poses a major health risk. This study assessed the impact of a healthy lifestyle on all‐cause and cardiovascular disease (CVD) mortality in CKM individuals.

Aging rises, yet the double burden of illness remains

Association of Accelerometer‐Derived Physical Activity with Incident Cardiovascular Diseases and Mortality in People With Severe Mental Illness

Cardiovascular vascular disease (CVD) is a leading cause of increased mortality in people with severe mental illness (SMI). This study aims to examine the dose–response and intensity‐specific associations between physical activity (PA) and CVD risk and mortality in people with SMI.

Dynamic Co‐Evolution of Obesity‐Metabolic‐Inflammatory for Cardiovascular Disease Risk Stratification in Middle‐Aged and Older Adults: A Data‐Driven Joint Trajectory Analysis

Cardiovascular disease (CVD) risk assessment based on single‐time‐point measurements may inadequately capture the dynamic interplay of obesity, metabolic dysfunction, and chronic inflammation. Understanding their long‐term co‐evolution may improve CVD risk stratification.

Epigenetic aging in Alzheimer's disease: Relation to proteome

Alzheimer's disease (AD) arises from heterogeneous biological processes, and long‐term environmental exposures may become biologically embedded, as reflected in epigenetic clocks.