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: Findings from the European prospective

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TL;DR

Results suggest that total consumption of fruits and vegetables is not related to risk of RCC, although the possibility that very low consumption is related to higher risk is not excluded, although the possibility that very low consumption is related to higher risk is not.

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Aug 2026

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A possible protective role for magnesium is supported and potential biases warrant cautious interpretation, and these findings support a possible protective role for magnesium and highlight the need for further large prospective studies.

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The Association of Diabetes-related Dietary Patterns with Pancreatic Cancer Risk in the European Prospective Investigation into Cancer and Nutrition study.

BACKGROUND Pancreatic cancer is relatively rare but remains one of the most lethal tumors. Identifying modifiable risk factors is a crucial step to reduce disease burden. Evidence suggests a potential role of type 2 diabetes mellitus in its pathogenesis. OBJECTIVE To examine the association between dietary patterns related to diabetes and pancreatic cancer risk in a European population. METHODS A total of 367,395 participants from the European Prospective Investigation into Cancer and Nutrition study were included. After a median follow-up of 14.9 years, 926 incident cases were identified. The Diabetes Risk Reduction Diet (DRRD), the Empirical Dietary Index for Hyperinsulinemia (EDIH) and the Empirical Dietary Index for Insulin Resistance (EDIR) were estimated from food frequency questionnaires at recruitment. Hazard ratios (HRs) and 95% confidence intervals (CI) for the association between dietary patterns and pancreatic cancer were calculated using multivariable Cox proportional hazards regression models, adjusted for relevant confounders. RESULTS Adherence to DRRD showed no association with risk of pancreatic cancer (HRT3vsT1 = 0.94, 95% CI 0.79-1.12). Higher adherence to EDIH was associated with a borderline 19% increased pancreatic cancer risk (HRT3vsT1 = 1.19, 95% CI 0.99-1.44). No significant associations were observed in relation to EDIR. No heterogeneity was observed among the subgroups. CONCLUSIONS Higher adherence to a hyperinsulinemic dietary pattern may contribute to the risk of developing pancreatic cancer in our population. Further research is warranted to elucidate the potential role of dietary factors in cancer risk prevention.

L.F. Torres-Laiton, W. Balcerzak, R. Zamora et al. · 0 citations
Open access Aug 2026

Fruit and vegetable consumption, dietary and plasma carotenoids and risks of recurrence and progression in patients with non-muscle-invasive bladder cancer

Fruit and vegetable consumption may decrease bladder cancer risk, but research on its relation to outcomes of non-muscle-invasive bladder cancer (NMIBC) is scarce. We investigated the association of (changes in) pre- and postdiagnosis fruit and vegetable consumption, as well as postdiagnosis dietary and plasma carotenoids, with risks of recurrence and progression in patients with NMIBC. Data from patients with newly diagnosed NMIBC between 2014 and 2021 from the prospective multi-centre cohort UroLife was used. Patients reported prediagnosis diet (n = 1396), and diet at 3 and 15 months postdiagnosis (n = 1270). Plasma carotenoid concentrations were measured at 3 and 15 months postdiagnosis (n = 910). Multivariable proportional hazards regression analyses were performed to assess associations with risks of first recurrence, multiple recurrences, and progression. Median follow-up time was 4.7 years, 466 patients had at least one recurrence, 139 had multiple recurrences, and 153 showed progression. Total fruit and vegetable consumption at 3 months postdiagnosis as well as pre-to-postdiagnosis increases in consumption were inversely associated with first recurrence risk (per 100 g/day: hazard ratio [HR] = 0.91, 95% confidence interval ([95%CI] 0.85–0.99 and HR = 0.90, 95%CI 0.81–0.99, respectively). Results were attenuated at 15 months after diagnosis. Total and individual dietary and plasma carotenoids were not associated with first recurrence risk. No associations with multiple recurrences and progression, and for prediagnosis fruit and vegetable consumption were found. Higher postdiagnosis fruit and vegetable consumption may have a beneficial role in NMIBC recurrence but not progression risk while no associations for dietary and plasma carotenoids were found.

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