The risks of gastric cancer and esophageal adenocarcinoma associated with meat consumption within the European Prospective Investigation Into Cancer and Nutrition (EPIC) cohort were examined.
BACKGROUND
Pancreatic cancer is relatively rare but remains one of the most lethal tumors. Identifying modifiable risk factors is a crucial step to reduce disease burden. Evidence suggests a potential role of type 2 diabetes mellitus in its pathogenesis.
OBJECTIVE
To examine the association between dietary patterns related to diabetes and pancreatic cancer risk in a European population.
METHODS
A total of 367,395 participants from the European Prospective Investigation into Cancer and Nutrition study were included. After a median follow-up of 14.9 years, 926 incident cases were identified. The Diabetes Risk Reduction Diet (DRRD), the Empirical Dietary Index for Hyperinsulinemia (EDIH) and the Empirical Dietary Index for Insulin Resistance (EDIR) were estimated from food frequency questionnaires at recruitment. Hazard ratios (HRs) and 95% confidence intervals (CI) for the association between dietary patterns and pancreatic cancer were calculated using multivariable Cox proportional hazards regression models, adjusted for relevant confounders.
RESULTS
Adherence to DRRD showed no association with risk of pancreatic cancer (HRT3vsT1 = 0.94, 95% CI 0.79-1.12). Higher adherence to EDIH was associated with a borderline 19% increased pancreatic cancer risk (HRT3vsT1 = 1.19, 95% CI 0.99-1.44). No significant associations were observed in relation to EDIR. No heterogeneity was observed among the subgroups.
CONCLUSIONS
Higher adherence to a hyperinsulinemic dietary pattern may contribute to the risk of developing pancreatic cancer in our population. Further research is warranted to elucidate the potential role of dietary factors in cancer risk prevention.
L.F. Torres-Laiton, W. Balcerzak, R. Zamora et al.· Journal of NutriLife· 0 citations
There was little evidence of an overall association between alcohol intake and stomach cancer risk, although modest positive associations were observed among never smokers and in Asian cohorts.
H. Jayasekara, Mo-Lin Wang, Yang Peng et al.· JNCI Cancer Spectrum· 0 citations
Results suggest that total consumption of fruits and vegetables is not related to risk of RCC, although the possibility that very low consumption is related to higher risk is not excluded, although the possibility that very low consumption is related to higher risk is not.
S. Weikert, H. Boeing, T. Pischon et al.· 0 citations
Throughout recent years, pancreatic cancer has been recorded as having one of the lowest survival rates among major cancers. As incidence rates continue to rise globally, identifying risk factors has become increasingly important. This review examines the relationship between dietary factors, particularly ultra-processed foods and added sugars, and the risk of pancreatic cancer development. This review synthesizes evidence from many epidemiological and clinical studies to evaluate the potential role of diet in the development of this malignant disease. Current literature suggests that a higher consumption of ultra-processed foods is associated with pancreatic cancer, however findings vary across populations and study designs. Overall, an analysis of these studies indicates that the consumption of ultra-processed foods may increase the chances of developing pancreatic cancer, mostly via induction or enhancement of chronic inflammation. Despite the conclusions of this review, further longitudinal and mechanistic studies are needed to determine the relationship between diet and the development of pancreatic cancer.
Saranyakumar Chigurupati, Prahlad Parajuli, Kay Diaz· Journal of High School Resea...· 0 citations
Overall, MetS and the accumulation of its components were associated with a moderately increased risk of gastric cancer, and waist circumference showed the most consistent component-level signal.
Gang-Qiang Wang, Shi-Rui Li, Si-Yu Li et al.· Cancer Research Communicatio...· 0 citations
RCS analyses identified nonlinear associations between fruit intake and the risks of overall and lung cancer, with the protective associations becoming less pronounced at excessive intake levels.
Jun Li, X. Yin, Gen-Ming Zhao et al.· International Journal of Can...· 0 citations
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