An HOCl-responsive chemiluminescent probe for monitoring MPO-mediated HOCl generation for deep-tissue tracking and evaluation of inflammatory bowel disease.

Qiang-Chao Meng Run-Sha Xiao Ji-Peng Ding Tian-Yu Zhu Jun-Pu Wang Cheng-Min Li Xue-Ping Feng Wen-Bin Zeng

Oct 2026 · Journal of materials chemistry. B · Vol 14, pp. 12746-12750 · 0 citations

Medicine

TL;DR

2TPA-IsoL, a novel chemiluminescent probe with red-shifted emission (600 nm), high HOCl selectivity, and prolonged kinetics, enables deep-tissue imaging and therapeutic evaluation of inflammatory bowel disease, offering a generalizable strategy for long-wavelength chemiluminescent probe design.

Abstract

By engineering the donor-acceptor scaffold of isoluminol, we developed 2TPA-IsoL, a novel chemiluminescent probe with red-shifted emission (600 nm), high HOCl selectivity, and prolonged kinetics. It enables deep-tissue imaging and therapeutic evaluation of inflammatory bowel disease, offering a generalizable strategy for long-wavelength chemiluminescent probe design.

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