A peroxynitrite-activatable NIR fluorescent and photoacoustic dual-modal probe for drug-induced liver injury imaging.

Abstract

A peroxynitrite-activatable NIR fluorescent/photoacoustic probe (ONOO--OBDP) was developed for detecting drug-induced liver injury. Specific ONOO- cleavage induced a bathochromic shift (745→822 nm) and an 18-fold fluorescence enhancement at 906 nm, enabling rapid, selective dual-modal imaging of hepatic ONOO- in animal models.