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Flexible use of conserved motifs constrains genome access in cell type evolution

Chew Chai Jesse Gibson Peng-Yang Li Brennan D. McDonald Anusri Pampari Aman Patel A. Kundaje Bo Wang
Sep 2026 · Nature Ecology & Evolution · Vol 10, pp. 1941 - 1958 · 1 citation · 94 references
Medicine

TL;DR

This work proposes a 'collective maintenance' model in which motif vocabularies defining cell type families are evolutionarily stable, while recombination of these motifs generates cell type-specific regulatory programmes.

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