P1.063. Development of a Machine Learning-Based Programmed Cell Death Genes Prognostic Model for Esophagea Carcinoma
TL;DR
A novel EC PCDRGs model is developed which could predict the prognosis and drug treatment sensitivity of EC patients in the future based on further validation.
Abstract
Esophageal Cancer: Molecular Biology/Pathology To use bioinformatics methods to evaluate the prognostic value of Programmed Cell Death Related Genes (PCDRGs) in esophageal carcinoma (EC), and to explore the development and immune regulatory mechanisms of EC from multiple perspectives. Using TCGA, GSE53622 data sets, and downloaded key regulatory genes of 18 PCD patterns, combined with 10 different machine learning methods to develop a prediction model, named this model ‘Characteristics of Cell Deaths’ (CDS). Seven prognosis-related genes were screened out by the model. The correlationbetween these seven genes and EC was analyzed. The PCDRGs prognostic model developed using the StepCox[both] + RSF method performed the best. CDS showed significant and powerful performance in predicting EC clinical outcomes and was able to serve as an independent risk factor in TCGA and GEO datasets. This study successfully developed a novel EC PCDRGs model, which could predict the prognosis and drug treatment sensitivity of EC patients in the future based on further validation.