Background Neoadjuvant chemoradiotherapy (NCRT) is standard for locally advanced esophageal squamous cell carcinoma (ESCC), while neoadjuvant immune-chemotherapy (NICT) is a promising alternative. This study compared pathological response and long-term survival between NICT and NCRT followed by surgery using a target t...
Zhi-Yu Li, Qiu-Xi Zhou, Qin Xie et al.· Frontiers in Immunology· 0 citations
Esophageal Cancer: Other
Precise segmentation of esophageal squamous cell carcinoma (ESCC) lesions on CT imaging is essential for treatment planning. While the Segment Anything Model for 3D medical images (SAM-Med3D) shows promise, its performance in delineating tumor boundaries remains suboptimal. We prop...
Si-miao Lu, Yi Zhu, Yong-Tao Han et al.· Diseases of the esophagus· 0 citations
Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications
The prognostic impact of type 2 diabetes in esophageal cancer patients receiving neoadjuvant therapy followed by surgery remains unclear. We evaluated its association with perioperative outcomes and long-term surv...
Xi-Peng Wang, Zhi-Chao Liu, Xue-Feng Leng et al.· Diseases of the esophagus· 0 citations
A novel EC PCDRGs model is developed which could predict the prognosis and drug treatment sensitivity of EC patients in the future based on further validation.
Si-Han Lu, Yi Zhu, Yong-Tao Han et al.· Diseases of the esophagus· 0 citations
Findings support RAMIE as a viable alternative with comparable patient-centered outcomes, though the higher anastomotic leak rate warrants further investigation.
Si-miao Lu, Yi Zhu, Yong-Tao Han et al.· Diseases of the esophagus· 0 citations
A retrospective analysis of a prospectively maintained international multicenter database comprising 2,490 patients who underwent curative-intent esophagectomy across four centers found three-field lymphadenectomy uniquely confers high recurrent laryngeal nerve palsy and chylothorax rates despite low mortality.
Si-miao Lu, Yi Zhu, Yong-Tao Han et al.· Diseases of the esophagus· 0 citations
In this international multicenter analysis of 2,449 ESCC patients, neoadjuvant therapy was not associated with improved survival after esophagectomy and remained an independent predictor of worse OS and DFS across univariate, multivariable, PSM, and IPTW analyses.
Si-miao Lu, Yi Zhu, Qiulin Shi et al.· Diseases of the esophagus· 0 citations
Symptom persistence does not adversely affect overall survival; its association with improved DFS likely reflects the tumor-control benefit of adjuvant therapy.
Si-miao Lu, Yi Zhu, Yong-Tao Han et al.· Diseases of the esophagus· 0 citations
An end-to-end multimodal AI system can accurately automate PRO assessment from natural patient conversations and provide clinically meaningful early warning for postoperative complications, with external validation confirming generalisability across cohorts.
Si-miao Lu, Yi Zhu, Yong-Tao Han et al.· Diseases of the esophagus· 0 citations
Surgical timing, particularly esophagectomy performed in February, is associated with inferior long-term survival in ESCC patients, and concurrent low burnout levels during this period suggest that reduced surgical volume and altered case selection during the holiday season, rather than staff fatigue, may underlie this...
Si-miao Lu, Yi Zhu, Yong-Tao Han et al.· Diseases of the esophagus· 0 citations
Standard preoperative variables are insufficient for individualized risk stratification of RLNP, anastomotic leak, or vocal cord palsy after esophagectomy, and improved prediction will require prospective integration of real-time intraoperative data.
Si-miao Lu, Yi Zhu, Yong-Tao Han et al.· Diseases of the esophagus· 0 citations
A multimodal early warning system integrating PROs, laboratory trajectories, and large language model-extracted clinical text features to enable real-time, automated complication surveillance substantially outperforms single-modality approaches for detecting postoperative complications after esophagectomy.
Si-miao Lu, Yi Zhu, Yong-tao Han et al.· Diseases of the esophagus· 0 citations
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