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Qiulin Shi

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Open access Aug 2026

PD05.07. Enhancing SAM-Med3D with Prototype-Contrast Boundary Optimization for Esophageal Squamous Cell Carcinoma Segmentation

Esophageal Cancer: Other Precise segmentation of esophageal squamous cell carcinoma (ESCC) lesions on CT imaging is essential for treatment planning. While the Segment Anything Model for 3D medical images (SAM-Med3D) shows promise, its performance in delineating tumor boundaries remains suboptimal. We prop...

Si-miao Lu, Yi Zhu, Yong-Tao Han et al. · 0 citations
Open access Aug 2026

P1.071. Perioperative Patient-Reported Outcomes After Robot-Assisted Versus Conventional Minimally Invasive Esophagectomy for Esophageal Squamous Cell Carcinoma: A Propensity Score-Matched Analysis

Findings support RAMIE as a viable alternative with comparable patient-centered outcomes, though the higher anastomotic leak rate warrants further investigation.

Si-miao Lu, Yi Zhu, Yong-Tao Han et al. · 0 citations
Aug 2026

P1.067. Multinational Comparison of Surgical Approaches and Postoperative Outcomes in Esophageal Cancer: An International Multicenter Cohort Study

A retrospective analysis of a prospectively maintained international multicenter database comprising 2,490 patients who underwent curative-intent esophagectomy across four centers found three-field lymphadenectomy uniquely confers high recurrent laryngeal nerve palsy and chylothorax rates despite low mortality.

Si-miao Lu, Yi Zhu, Yong-Tao Han et al. · 0 citations
Open access Aug 2026

P1.072. Impact of Neoadjuvant Therapy on Survival After Esophagectomy for Squamous Cell Carcinoma: An International Multicenter Propensity Score Analysis

In this international multicenter analysis of 2,449 ESCC patients, neoadjuvant therapy was not associated with improved survival after esophagectomy and remained an independent predictor of worse OS and DFS across univariate, multivariable, PSM, and IPTW analyses.

Si-miao Lu, Yi Zhu, Qiulin Shi et al. · 0 citations
Open access Aug 2026

PD02.06. The ``Invisible Cost'' After Minimally Invasive Esophagectomy: Clinical Characteristics, Survival Impact, and Intervention Timing for Patients with Persistent Moderate-to-Severe Symptoms

Symptom persistence does not adversely affect overall survival; its association with improved DFS likely reflects the tumor-control benefit of adjuvant therapy.

Si-miao Lu, Yi Zhu, Yong-Tao Han et al. · 0 citations
Open access Aug 2026

PD08.07. Multimodal AI-Driven Postoperative Surveillance for Oesophageal Cancer: Automated Patient-Reported Outcome Assessment and Early Complication Warning in a Prospective Study

An end-to-end multimodal AI system can accurately automate PRO assessment from natural patient conversations and provide clinically meaningful early warning for postoperative complications, with external validation confirming generalisability across cohorts.

Si-miao Lu, Yi Zhu, Yong-Tao Han et al. · 0 citations
Review Aug 2026

P1.070. Exploring the Association Between Month of Esophagectomy and Long-Term Survival Outcomes : a Large-Scale Survival Study Combined Questionnaire Survey Analysis

Surgical timing, particularly esophagectomy performed in February, is associated with inferior long-term survival in ESCC patients, and concurrent low burnout levels during this period suggest that reduced surgical volume and altered case selection during the holiday season, rather than staff fatigue, may underlie this...

Si-miao Lu, Yi Zhu, Yong-Tao Han et al. · 0 citations
Open access Aug 2026

P1.064. Limitations of Preoperative Prediction Models for Complications After Esophagectomy: A Multi-Center Analysis

Standard preoperative variables are insufficient for individualized risk stratification of RLNP, anastomotic leak, or vocal cord palsy after esophagectomy, and improved prediction will require prospective integration of real-time intraoperative data.

Si-miao Lu, Yi Zhu, Yong-Tao Han et al. · 0 citations
#protein folding Aug 2026

OA01.4. Multimodal Early Warning System for Postoperative Complications After Esophagectomy: Integrating Patient-Reported Outcomes, Laboratory Trajectories, and Clinical Text Mining

A multimodal early warning system integrating PROs, laboratory trajectories, and large language model-extracted clinical text features to enable real-time, automated complication surveillance substantially outperforms single-modality approaches for detecting postoperative complications after esophagectomy.

Si-miao Lu, Yi Zhu, Yong-tao Han et al. · 0 citations
#protein folding Open access Aug 2026

P1.069. Distinct Postoperative CRP Trajectory Patterns and Their Association With Complication Severity Following Esophagectomy

Postoperative CRP trajectory patterns are significantly associated with complication severity after esophagectomy, and the High-Persistent trajectory identifies a high-risk subgroup, and the D3/D1 ratio enables early risk stratification by POD 3.

Si-miao Lu, Yi Zhu, Yong-tao Han et al. · 0 citations
#protein folding Aug 2026

P1.062. Discovery of Novel Dual-Target Inhibitors for EGFR and PIK3CA From Natural Products via Machine Learning and Molecular Simulation

The natural product compounds CNP0456830 and CNP0467494 exhibited the lowest binding free energies for both EGFR and PIK3CA, identifying them as the most promising dual-target inhibitors.

Si-miao Lu, Yi Zhu, Yong-Tao Han et al. · 0 citations

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