Open access
Unraveling the roles of DKK1 and S100P in pancreatic ductal adenocarcinoma: Insights from machine learning, single-cell/spatial transcriptomics, and functional validation
Yanzhao Mao
Yu-Qi Zhang
Yu-Peng Zhang
Dongwei Lin
Yue-Lin Song
Xiaojiang Niu
Peihao Xv
Yuliang Wang
Zhi-Gang Wei
Medicine
Abstract
Highlights • Multi-omics integration and machine learning identified DKK1 and S100Pas PDAC prognostic genes.• scRNA-seq and spatial transcriptomics revealed distinct expression patterns in the tumor microenvironment.• Functional assays confirmed that DKK1 and S100P significantly promote PDAC cell proliferation and migration.