Author

Yanzhao Mao

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Open access Jul 2026

Unraveling the roles of DKK1 and S100P in pancreatic ductal adenocarcinoma: Insights from machine learning, single-cell/spatial transcriptomics, and functional validation

Highlights • Multi-omics integration and machine learning identified DKK1 and S100Pas PDAC prognostic genes.• scRNA-seq and spatial transcriptomics revealed distinct expression patterns in the tumor microenvironment.• Functional assays confirmed that DKK1 and S100P significantly promote PDAC cell proliferation and migration.

Yanzhao Mao, Yu-Qi Zhang, Yu-Peng Zhang et al. · Translational Oncology · 0 citations

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