Author

Dongwei Lin

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Open access Jul 2026

Unraveling the roles of DKK1 and S100P in pancreatic ductal adenocarcinoma: Insights from machine learning, single-cell/spatial transcriptomics, and functional validation

Highlights • Multi-omics integration and machine learning identified DKK1 and S100Pas PDAC prognostic genes.• scRNA-seq and spatial transcriptomics revealed distinct expression patterns in the tumor microenvironment.• Functional assays confirmed that DKK1 and S100P significantly promote PDAC cell proliferation and migration.

Yanzhao Mao, Yu-Qi Zhang, Yu-Peng Zhang et al. · Translational Oncology · 0 citations

Review Open access Aug 2026

Interconnected roles of cellular senescence and the immune microenvironment in tumor progression: from pan-cancer mechanisms to glioblastoma implications

This review systematically examines the molecular mechanisms of cellular senescence, with emphasis on the intrinsic logic governing bidirectional remodeling between senescent cells and the immune microenvironment, to provide a new theoretical foundation for next-generation precision cancer immunotherapy.

Wen-Wen Zhao, Pengfei Zhang, Li-Xin Li et al. · Cell Death Discovery · 0 citations