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TCGA-based identification and functional validation of PBK in intrahepatic cholangiocarcinoma progression with involvement of AKT signaling

Xiang-Tian Shi Lei Zhang Tengqi Wang Meng Wang Chao Wang Zhan Liu Gui-Xin Zhang
Aug 2026 · Translational Oncology · Vol 72, pp. 102977 · 0 citations · 34 references
Medicine

Abstract

Highlights • Integrated TCGA analysis via DESeq2, edgeR, limma & WGCNA identified PBK as key ICC gene.• PBK overexpressed in ICC, correlates with tumor stage.• PBK promotes ICC progression via AKT pathway activation; inhibitor abrogates oncogenic effects.• PBK knockdown suppresses xenograft growth with reduced p-AKT, KI67 and PCNA expression.

DOI PubMed Semantic Scholar
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