Multi‐omics identification of haptoglobin as a novel target for increased Alzheimer's disease risk associated with obesity through inhibiting the phagocytosis of Aβ by disease‐associated microglia

Dissecting Alzheimer's proteomic landscape through NULISA profiling of brain cell‐specific extracellular vesicles

Blood‐based biomarkers are essential for early detection, monitoring, and therapeutic development in Alzheimer's disease (AD) and related dementia (ADRD), but current assays lack brain cell specificity and sensitivity to low‐abundant proteins.

Reactivities of endocannabinoids toward metal-induced amyloid-β aggregation and oxidative stress associated with Alzheimer's disease

Endocannabinoids are endogenous lipid-based signaling molecules that coexist in the synaptic cleft with key pathological factors of Alzheimer’s disease (AD), including metal ions, amyloid-β (Aβ), and reactive oxygen species (ROS)....

Immunosuppressant Use Mediates Neuroprotection Against Alzheimer's Disease in Rheumatoid Arthritis—A Two‐Step Mendelian Randomization and NHANES Study

To investigate whether immunosuppressant (IS) use contributes to the inverse association between rheumatoid arthritis (RA) and Alzheimer's disease (AD).

Deciphering the role of histidine in cancer

Design of bifunctional pyridinophane ligands as Mn 2+ MRI agents for diagnostic imaging of Alzheimer's disease

Alzheimer's disease (AD) is a progressive neurodegenerative disorder whose prevalence is rising with the aging of the global population. Among the proposed pathological hallmarks, the amyloid-beta (Aβ) peptide aggregates and...

Complementary Mitochondrial and α‐Synuclein Signatures Refine Biological Stratification of Parkinson's Disease

We read with interest the Viewpoint by Percetti and colleagues proposing the concept of a biologically de fi ned mitochondrial subtype of Parkinson ’ s disease (PD) ( “ MitoPD