Exploring ageing as a potential new therapeutic target for schizophrenia.

Genetic and environmental risk factors of Parkinsonism

Parkinsonian disorders comprise a broad spectrum of neurodegenerative diseases with a wide variety of pathogenetic processes. These processes lead to the formation of pathological proteins, resulting in the brain diseases called synucleinopathies, tauopathies or TDP-43 proteinopathies. There is currently growing suppor...

Epigenetic aging in Alzheimer's disease: Relation to proteome

Alzheimer's disease (AD) arises from heterogeneous biological processes, and long‐term environmental exposures may become biologically embedded, as reflected in epigenetic clocks.

Parkinson's gene linked to early dysfunction in brain cells

Revealing the Mechanisms of Alzheimer’s, Parkinson’s and Huntington’s Diseases Through Invertebrate Models

The conserved mechanisms underlying the occurrence of three neurodegenerative diseases across species are reviewed, with a focus on major studies involving three invertebrate models.

Epigenetic Mechanisms Underlying Cognitive Dysfunction in Parkinson's Disease: Current Evidence and Future Prospects

The purpose of this review is to explore how epigenetic alterations affect gene expression and their potential role in cognitive dysfunction associated with PD.

Elucidating the neuropathological and molecular heterogeneity of amyloid beta and tau in Alzheimer's disease through machine learning and transcriptomic integration

Functional brain network alterations associated with Alzheimer's disease (AD) pathology, including amyloid beta (Aβ) and phosphorylated tau (p‐tau), are difficult to interpret due to overlapping aging‐associated and non‐amyloid biological processes.