Parkinson's gene linked to early dysfunction in brain cells

Parkinson's-linked gene holds clues to battling deadly bacterial infections

Single‐cell atlas of neuroglial dynamics in SNCA‐A53T Parkinson's disease mouse model

This data indicates that suppression of dopaminergic neurons in the substantia nigra results in striatal dopamine depletion and motor dysfunction in Parkinson's disease, and further studies are needed to establish a specific mechanism behind this phenomenon.

Exploring ageing as a potential new therapeutic target for schizophrenia.

Increased age-related biological changes have been causally linked to various pathologies in the brain, including Alzheimer's and Parkinson's diseases. There is also evidence that schizophrenia could be included in this group of brain disorders that may actually be manifestations of a broader multisystemic premature ag...

Genetic and environmental risk factors of Parkinsonism

Parkinsonian disorders comprise a broad spectrum of neurodegenerative diseases with a wide variety of pathogenetic processes. These processes lead to the formation of pathological proteins, resulting in the brain diseases called synucleinopathies, tauopathies or TDP-43 proteinopathies. There is currently growing suppor...

Timing the Alzheimer's disease pathological cascade.

This scientific commentary refers to ‘Modelling the temporal evolution of plasma p-tau217, amyloid PET, tau PET and cognition’ by Cogswell et al. (https://doi.org/10.1093/brain/awag075).

Levels of gene-expression-regulating enzyme altered in brains of people with schizophrenia