Open access
Proximity labeling puts ZFP36L1 as central hub for posttranscriptional regulation networks in T cells
Anouk P. Jurgens
Branka Popović
Floris P. J. van Alphen
M. Steinmetz
Leyma Wardak
Antonia Bradarić
Sander Engels
C. van der Zwaan
M. van den Biggelaar
Arie J. Hoogendijk
Julien Béthune
M. Wolkers
Medicine
Abstract
RNA binding proteins (RBPs) are key regulators of controlling the proteome remodeling during T-cell activation. Using proximity labeling, we present a comprehensive interactome map of the RBP ZFP36L1, demonstrating the versatility of interactions and their possible functioning during T-cell activation.