PCBP1 joins the regulatory network of the endothelial-to-hematopoietic transition.

Proximity labeling puts ZFP36L1 as central hub for posttranscriptional regulation networks in T cells

Using proximity labeling, a comprehensive interactome map of the RBP ZFP36L1 is presented, demonstrating the versatility of interactions and their possible functioning during T-cell activation.

ID2 orchestrates the final ‘E-scape’ from the −165-kb Zeb2 enhancer for cDC1 specification

Milking the niche: Microbial control of neonatal hematopoiesis.

In this issue of Cell, Howard et al. reveal how the milk glycoprotein osteopontin shapes the neonatal microbiome to regulate hematopoiesis, promoting dendritic cell development and protection from severe respiratory infection. These findings uncover a maternal milk-microbiota pathway linking early-life nutrition to imm...

Corrigendum to "Global comprehensive transcriptomic and proteomic analyses of murine terminal erythroid differentiation" [Glob. Med. Genet. 12 (2025) 100083].

[This corrects the article DOI: 10.1016/j.gmg.2025.100083.].

A genetically regulated SKAP2 switch modulates human T lymphocyte adhesion and migration

Spinella et al. linked a Crohn’s disease risk allele regulating SKAP2 expression to T lymphocyte function. SKAP2 enhances cell adhesion while suppressing migration. Sustained TCR signaling triggers its proteolytic cleavage to enable migration. Overall, genetic alteration of SKAP2 levels drives T cell dysfunction and pr...

Malaria durably disrupts macrophage-to-macrophage crosstalk in the spleen.

Blood-stage malaria transiently depletes and remodels splenic macrophages, but how distinct subsets recover remains unclear. A recent report by Mauel et al. shows that a yolk sac-derived CD163high red pulp macrophage subset is selectively and durably lost after malaria, disrupting a growth differentiation factor 15-dep...