Intrinsically disordered regions (IDRs)-the proteome dark matter-confer dynamic adaptability upon rigid protein scaffolds. How IDRs and their adjacent folded domain (context) modulate enzyme substrate promiscuity and calibrate host-specific immune outputs remains unknown. Addressing this knowledge gap has substantial e...
Indeterminate cell histiocytosis (ICH) is a clonal proliferative disorder of mononuclear phagocyte cells that shows features of both dendritic and histiocytic cells. Only around 100 cases of ICH were reported, and among them, only 24% of reported cases involve pediatric patients, with a mean age at diagnosis of 50 year...
Seung-Soo Lee, Seok-Jong Lee, Weon-Ju Lee et al.· Journal of cutaneous patholo...· 0 citations
This archive contains the complete analysis notebook (canlung_dissociation_final.ipynb) accompanying Jacobs, Detectable and Lethal Lung Cancer Are the Same Proteomic Disease (2026), the third study in a trilogy examining whether the circulating proteins that predict cancer detection differ from those that predict cance...
Laurence A Jacobs· Zenodo (CERN European Organi...· 0 citations
Abstract: This paper and accompanying master dataset present a complete, first-principles derivation of the fine-structure constant ($\alpha$) and unified energy states, bypassing standard quantum electrodynamic (QED) infinities and empirical curve-fitting. Utilizing a deterministic, non-Cartesian charge-pond framework...
Robert Weber· Zenodo (CERN European Organi...· 0 citations
Reach audiences
Advertise in front of researchers, engineers, and readers.
EnzyDiff is a lightweight, reproducible, and interpretable framework for enzyme activity direction classification that encodes mutation-induced activity perturbations from enzyme sequences before and after mutation, together with mutation identity and position.
Chikungunya virus (CHIKV) replication relies on the multifunctional nsP2 protein, making it an attractive target for antiviral drug discovery. Here, we report the resolution of oxaspiropiperidine 1, a first-in-class inhibitor of the CHIKV nsP2 RNA helicase (nsP2hel), into its constitutive enantiomers and characterizati...
Mark T. Heise, Shubin Liu, Levon Halabelian et al.· UNC Libraries· 0 citations
To characterize irradiation-associated transcriptomic changes in murine triple-negative breast cancer cells and examine dose- and time-response patterns of selected radiation-responsive candidates. RNA sequencing (RNA-seq) was performed in 4T1 cells collected 24 h after 4 Gy irradiation, followed by Reactome and Kyoto...
Methyl 12-aminododecanoate (ADAME) is a key precursor for Nylon 12 synthesis and an attractive target for sustainable microbial production. However, efficient biosynthesis of ADAME requires the coordinated oxidation and transamination of methyl dodecanoate (DAME), and identifying compatible enzymes for this multistep p...
Myco Umemura, Yasushi Kamisaka, Masaki Yamamoto et al.· bioRxiv (Cold Spring Harbor...· 0 citations
There may be an association between ferroptosis-related pathways and cuproptosis-related pathways in RA and suggest that FTH1, SOD2, and CDKN2A are candidate biomarkers and candidate therapeutic targets.
Abbas Ahmad, Shehzad Khalil, Douglas Law et al.· PLoS ONE· 0 citations
Introduction: The use of Δ8-tetrahydrocannabinol (Δ8-THC) has become increasingly prevalent in the United States, but its metabolic pathways remain poorly characterized. This study aimed to identify the key enzymes responsible for the 11′-hydroxylation of Δ8-THC, its primary metabolic pathway, and assess the effect of...
Meng-Qi Zhao, Philip Lazarus· Pharmaceutics· 0 citations
A growing number of studies have detected nanoplastics, particularly polystyrene (PS) nanoparticles, in human blood and various critical tissues. Nevertheless, the molecular mechanisms by which their physical size modulates the aggregation of disease-related proteins remain poorly understood. Here, using well-tempere...
Kang Wang, Shuai Gong, Yi-Feng Sheng et al.· Langmuir· 0 citations
Background Venetoclax and selinexor are essential targeted agents for hematological malignancies, but their clinical application is challenged by pronounced ethnic pharmacokinetic differences—especially in Chinese patients—and CYP3A-mediated drug-drug interactions (DDIs) with azole antifungals (voriconazole, fluconazol...
Fei-Fei Han, Yin-Ying Wang, Y. Jian et al.· Frontiers in Pharmacology· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
