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1,977 papers
An antitumor peptide-based delivery platform in which both termini of a stapled p53 α-helix are linked via a disulfide bond, thereby repurposing nonpolar residues originally involved in target protein (hDM2) binding as a hydrophobic block that drives co-assembly with doxorubicin.
In this study, the synergistic cryoprotective efficacy of chicken skin collagen (CSC) and tamarind seed polysaccharide (TSP) was evaluated using hairtail surimi subjected to five freeze-thaw (F-T) cycles. It was revealed that 0.5% CSC and 0.5% TSP (CSC-TSP) composite significantly outperformed individual components and...
Introduction We investigated two siblings from a consanguineous Kurdish family presenting with a specific facial phenotype (prominent forehead, supraorbital ridges, broad nose, depressed nasal bridge), severe short stature with biochemical features of growth hormone (GH) deficiency, microcephaly, and developmental dela...
The pancreas consists of exocrine and endocrine compartments. In the exocrine pancreas, cystic fibrosis transmembrane conductance regulator (CFTR) functions mainly in ductal epithelial cells as a chloride and bicarbonate channel. Its activity depends on proper protein folding, trafficking, and localization to the apica...
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Discussion and ConclusionThe (ELUULK) 4 3 10 -helical bundle displays strongly position-dependent mutational tolerance.Surface residues can be readily substituted while preserving the 3 10 architecture, whereas the interfacial Aib positions and hydrophobic core impose much tighter geometric constraints.Computational an...
Global aquaculture has grown significantly, but to maintain current consumption, supply must double over the next 20 years. Here, we characterised the digestive and absorptive capacities in the intestines of three commercially important, farmed fish species with varying natural diets: Nile tilapia (Oreochromis niloticu...
A cationic nanobubble formulation capable of efficient DNA loading and ultrasound-dependent gene expression is presented, supporting a mechanism for selective and site-specific gene delivery.
Abstract: This paper and accompanying master dataset present a complete, first-principles derivation of the fine-structure constant ($\alpha$) and unified energy states, bypassing standard quantum electrodynamic (QED) infinities and empirical curve-fitting. Utilizing a deterministic, non-Cartesian charge-pond framework...
This archive contains the complete analysis notebook (canlung_dissociation_final.ipynb) accompanying Jacobs, Detectable and Lethal Lung Cancer Are the Same Proteomic Disease (2026), the third study in a trilogy examining whether the circulating proteins that predict cancer detection differ from those that predict cance...
This archive contains the complete analysis notebook (canlung_dissociation_final.ipynb) accompanying Jacobs, Detectable and Lethal Lung Cancer Are the Same Proteomic Disease (2026), the third study in a trilogy examining whether the circulating proteins that predict cancer detection differ from those that predict cance...
Intrinsically disordered regions (IDRs)-the proteome dark matter-confer dynamic adaptability upon rigid protein scaffolds. How IDRs and their adjacent folded domain (context) modulate enzyme substrate promiscuity and calibrate host-specific immune outputs remains unknown. Addressing this knowledge gap has substantial e...
Indeterminate cell histiocytosis (ICH) is a clonal proliferative disorder of mononuclear phagocyte cells that shows features of both dendritic and histiocytic cells. Only around 100 cases of ICH were reported, and among them, only 24% of reported cases involve pediatric patients, with a mean age at diagnosis of 50 year...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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