Atopic dermatitis (AD) is a chronic inflammatory skin disease marked by barrier dysfunction and immune dysregulation. Although IgE has been extensively implicated in AD pathogenesis, the functional role of polyclonal IgG remains poorly defined. We investigated whether IgG from adults with AD modulates peripheral immune...
Beatriz Oliveira Fagundes, Nicolle Rakanidis Machado, Lais Alves do Nascimento et al.· Cell & Bioscience· 0 citations
Scientific descriptions become useful through the work they let us do next: predict a response, combine observations, or reuse a result. A correct answer to one question can nevertheless discard a distinction that the next question requires. This paper develops RPRM Process Mechanics as a human-guided method for findin...
William J. Foster· Zenodo (CERN European Organi...· 0 citations
F-box proteins are important components of the SCF-E3 ubiquitin ligase complex, specifically regulating target protein abundance and participating in plant growth, development, and stress responses. In this study, an F-box gene responsive to salt stress, SmAMR1 , was cloned from Salix matsudana Koidz. It was 1209 bp lo...
Lei Wang, Junkang Zhang, Han Zhao et al.· Industrial Crops and Product...· 0 citations
The study assessed changes in energy, temporal, technological, environmental, and washing-quality parameters after introducing a central heat recovery system in an industrial laundry. Instrumental measurements, gravimetric and microbiological methods, textile mechanical testing, and calculations of energy-efficiency an...
J. Steller· Energy· 0 citations
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Conformational conversion of the cellular isoform of prion protein, designated PrP C , into the abnormally folded, amyloidogenic isoform, PrP Sc , plays a key pathogenic role in prion diseases, including Creutzfeldt-Jacob disease in humans. We previously reported that sortilin, a member of the vacuolar protein sorting...
Batzaya Batchuluun, Hironori Miyata, Nandita Rani Das et al.· Scientific Reports· 0 citations
This study evaluated a bioprocess using the thermo-acidophilic red microalga
Galdieria sulphuraria
to convert shrimp- and sludge-derived residues into biomass and pigments. Shrimp residues contained 57% (w/w) protein and 11% (w/w) lipids, whereas sludge contained 28–32% (w/w) protein and 13% (w/w) carbohydrates....
Corina Kleps, N. Händel, Stephanie Schönfelder et al.· Waste and Biomass Valorizati...· 0 citations
NADPH-cytochrome P450 reductase (CPR) serves as the obligate electron donor for cytochrome P450 enzymes and is essential for xenobiotic metabolism and detoxification. However, its involvement in insecticide resistance of Aphis spiraecola remains unclear. In this study, the open reading frame (ORF) of the A. spiraecola...
Shuo Zhang, Kang Wang, Yi You et al.· Frontiers in Physiology· 0 citations
Depression has a substantial genetic component. Protein folding and proteostasis pathways have been implicated in depression-related biology, but the genetically supported associations between specific protein folding-related genes and major depressive disorder (MDD) remain insufficiently understood. We applied summary...
Juan Wang, Shen He, Jun-Fang Cui et al.· Annals of General Psychiatry· 0 citations
Ataxia-telangiectasia (A-T) is a multisystemic genetic disorder caused by pathogenic mutations in the ATM gene, with effects extending beyond the canonical DNA damage response. We investigated whether two compact ATM transcript variants, ATM 4-53 (exons 4 and 53 joined) and ATM SINT (an in silico-designed ATM variant),...
Anastasia Ricci, Federica Biancucci, G. Morganti et al.· International Journal of Mol...· 0 citations
ALKBH5 is identified as a candidate host-cell engineering target for improving recombinant protein production and support further validation under industry-relevant fed-batch conditions.
Salmon skin, a high-volume by-product of seafood processing, offers a circular-bioeconomy route to sustainable, value-added ingredients. This study aimed to generate low-molecular-weight collagen peptides (LMWCPs) from salmon skin using a stepwise enzymatic process and to evaluate their safety and pro-extracellular-mat...
Sottawat Benjakul, Krisana Nilsuwan, Umesh Patil et al.· International Journal of Mol...· 0 citations
Scientific descriptions become useful through the work they let us do next: predict a response, combine observations, or reuse a result. A correct answer to one question can nevertheless discard a distinction that the next question requires. This paper develops RPRM Process Mechanics as a human-guided method for findin...
William J. Foster· Zenodo (CERN European Organi...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
