Peptide receptor radionuclide therapy with [177Lu]Lu-DOTATATE is an established treatment for somatostatin receptor–expressing neuroendocrine tumors. Although strong anti-tumor effects have been demonstrated in experimental models, curative responses in patients remain limited. Improved understanding of the molecular r...
J. Spetz, Mikael Montelius, Evelin Berger et al.· BMC Cancer· 0 citations
This thesis is devoted to the mechanical and topological properties of DNA, the repository of our genetic information. These properties are fundamental to abroad range of biological processes, essentially setting the ground rules for the organization of DNA and its interactions with the cellular machinery. We study phy...
The results indicate that in vitro TGF-β2 inhibition effectively reduces gene expression that can be significant for better targeting of hypoxia-modified cancer cells.
D. A. Dashkova, E. Dereviankin, E. Z. Lapkina et al.· Cell and Tissue Biology· 0 citations
It is demonstrated that forced intercalation can convert an RNA-binding peptide into a fluorogenic probe for ligand-displacement analysis and direct RNA detection.
Luo He, Yusuke Sato, S. Nishizawa· RSC Advances· 0 citations
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This study evaluated the combined effects of ultrasound-assisted hydration (25 kHz, 38 W/L, 20 min, 25 °C), followed by germination (72 h at 25 °C), and ultrasound-assisted mashing performed under 0 %, 50 %, or 100 % ultrasound application during each isothermal resting stage (25 kHz, 38 W/L, 25 °C). The effects of the...
F. C. Pacheco, Irene Andressa, Fabiana Nascimento de Carvalho et al.· Ultrasonics sonochemistry· 0 citations
It is suggested that IPF pathogenesis creates a permissive microenvironment for PFD through simultaneous enhancement of paracellular permeability and active cellular uptake through simultaneous enhancement of paracellular permeability and active cellular uptake.
Xiao-Ting Gu, Chao-Yue Zheng, Bo Li et al.· European Journal of Pharmace...· 0 citations
The sensitivity and specificity of ADC1 support its potential use as a diagnostic Ag for anaplasmosis and are consistent with AlphaFold v2 predictions, which further predict the core of P44 to be an eight-stranded β-barrel.
N. Cramer, K. Brangulis, Shane N. Mann et al.· Infection and Immunity· 0 citations
The structures of complexes formed by covalently linking CppB and CppA by X-ray crystallography and cryo-EM analysis allowed us to construct a three-dimensional structure model with dynamic motion of C. perfringens pili, and proposed new insights into the mechanism by which CppB is preferentially attached to CppA.
Yasuhiro Nonaka, E. Tamai, Hiroshi Sekiya et al.· The FEBS Journal· 0 citations
Eukaryotic cap‐dependent translation initiation is regulated by binding of the predominantly folded eukaryotic initiation factor 4E (eIF4E) to the intrinsically disordered eIF4E binding proteins (4E‐BPs). Here, we report full‐length atomistic conformational ensembles generated by IDPConformerGenerator and optimized by...
S. Smyth, Zi-Hao Liu, Thomas E. Tsangaris et al.· Protein Science· 0 citations
Late lactation is frequently accompanied by changes in goat milk composition and volatile-related quality, which may reduce its commercial value. This study investigated whether Astragalus polysaccharide (APS), a plant-derived bioactive polysaccharide from Astragalus membranaceus (Fisch.) Bunge, is associated with milk...
Shan-Shan Han, Peng Wang, Yun-Hong Hu et al.· Food Chemistry: X· 0 citations
Roles of FGF23 in P homeostasis in a large animal, healthy swine model were validated, with HP consumption stimulated bone FGF23 expression and renal adaptive responses in healthy pigs, consistent with roles of FGF23-mediated phosphaturia and regulation of vitamin D metabolism for maintenance of P homeostasis.
M. Grez-Capdeville, Brittney P. Kokinos, L. Amundson et al.· JBMR Plus· 0 citations
A mechanistic model in which selectivity for aggregated aSyn arises from an emergent mesoscale interface combining a polyelectrolyte brush with recurrent core hotspots is presented, establishing full‐length, brain‐derived fibril ensembles as a practical framework for understanding ligand recognition at amyloid surfaces...
Carlos Pintado-Grima, Oriol Bárcenas, G. Tesei et al.· Protein Science· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
