Abstract The circadian clock enables organisms to align internal daily rhythms with environmental cues, with major consequences for survival and fitness. Although the molecular framework of this system in Drosophila melanogaster is well characterized through transcription translation feedback loops involving ten core c...
Maya Yair, Bettina Fishman, Maya Aslan et al.· Heredity· 0 citations
Findings indicate that while protein–protein interactions may initiate LLPS, m6A-modulated RNA–protein interactions govern condensate growth and stability, and provide a mechanistic insight into how epitranscriptomic modifications regulate biomolecular condensation and influence cellular organization, gene regulation,...
Chamali Thalagaha Mudiyanselage, Milan Pandey, Sudeshi M. Abedeera et al.· ACS Bio & Med Chem Au· 0 citations
Small peptides have emerged as an important class of biologics with broad therapeutic applications. Limitations of conventional solid-phase synthesis have intensified the interest in microbial production systems.
Komagataella phaffii
, a widely used host for secretory protein production, represents a promising...
Johanna Pirchner, Simon Arhar, Corinna Odar et al.· Frontiers in Bioengineering...· 0 citations
BACKGROUND
The pea aphid, Acyrthosiphon pisum, is a damaging phloem-feeding pest of legume crops, and RNA interference (RNAi)-based targeting of stress-adaptation genes offers a promising route for target-specific pest management. Apolipoprotein D (ApoD) proteins are putative lipid carriers in insects, but the function...
Bing-Jin Wu, Xia Yang, S. Mobarak et al.· Pest Management Science· 0 citations
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ABSTRACT This study presents the discovery and characterization of a novel thermophilic 3-quinuclidinone reductase (ScQR) identified through metagenomic mining of hot spring environments. ScQR, a member of the short-chain dehydrogenase/reductase (SDR) superfamily, was heterologously expressed in Escherichia coli, and i...
D. Lou, Jing-Hao Cui, Jing-Fa Duan et al.· Applied and Environmental Mi...· 0 citations
Background: Although the impact of β-casein A1/A2 variants on human health is well-documented, the immunogenic potential of complex milk protein variants, including κ-casein (variants A, B, and E) and β-lactoglobulin (variants A and B) polymorphisms, remains poorly understood. This study aimed to evaluate ex vivo the c...
L. Markiewicz, Dagmara Złotkowska, A. Ogrodowczyk et al.· Nutrients· 0 citations
Enhancing the robustness of functional proteins remains a central challenge in biotechnology, with implications for catalysis, pharmaceuticals, and industrial synthesis. Enzyme immobilization in porous materials such as metal–organic frameworks (MOFs) is widely used to enhance enzyme stability; however, the structural...
Siene Swinnen, Maxim Lox, Marika Di Berto Mancini et al.· Journal of the American Chem...· 0 citations
Neuroendocrine prostate cancer (NEPC) is a lethal subtype of castration-resistant prostate cancer (CRPC) driven by therapy-induced lineage plasticity. While endoplasmic reticulum (ER) homeostasis is critical for cell fate determination and therapeutic response, the molecular mechanisms linking ER stress regulation to l...
Youjian Li, Yongshan Li, Shiyu Li et al.· Cellular and Molecular Life...· 0 citations
Heavy metals and metalloids are persistent environmental contaminants that accumulate in the central nervous system and interact with endogenous essential metals, yet most neurotoxicological research continues to treat metals as independent agents rather than as co-occurring mixtures. This review systematically compare...
I. Mitu, I. Caba, I. Macovei· Journal of Xenobiotics· 0 citations
Membrane transporters frequently exhibit internal structural symmetry, reflecting evolutionary origins through gene duplication and fusion events, and this feature has been widely used to infer transport mechanisms. Yet its application to the Zrt-/Irt-like protein (ZIP) family of divalent metal transporters, which are...
Yao Zhang, Tian-Qi Wang, Hong-Yan Zhao et al.· Protein Science· 0 citations
It is posited that miRNAs hold significant potential both as novel therapeutic targets and as pivotal regulators in deciphering the intricate pathogenesis of COVID-19 and requires the synergistic integration of in vivo and in vitro experimental approaches in conjunction with rigorous clinical investigations.
Gokce Kader Arslan, Mehmet Özdemir· Microorganisms· 0 citations
Coiled coils are formed by α‐helices winding around each other into superhelical bundles. They are characterized by a specific geometry of interaction, called knobs‐into‐holes, in which residues in the core of the structure mesh regularly along a seam that runs the length of the helices. While these residues are predom...
Marcus D. Hartmann, B. H. Alvarez, Mikel Martinez-Goikoetxea et al.· Protein Science· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
