AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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1,976 papers
MIRAGE (Measuring Interpolation and Redundancy in Affinity GEneralization), a plug-in benchmark treating historical public family support (through 2019) as an explicit variable, applying a family-support axis to affinity and pose prediction via matched strata, family-disjoint controls, ligand-only baselines, and tempor...
SoupFold is introduced, which improves co-folding predictions by learning simple mappings between the representation spaces of co-folding models, and achieves state-of-the-art performance on both protein-protein and protein-ligand structure prediction.
CHRAC17, a key coordinator of chromatin remoder and DNA polymerase ε (Polε), orchestrates sequential chromatin remodeling, nucleosome assembly and sliding, to promote RAD51-mediated HR and mobilize Polε, thereby ensuring genome stability.
It is shown that ESM-2 exhibits reduced attention on disordered regions, yet still encodes meaningful biological signals, and that both the radius of gyration and individual dynamic contact maps, key characteristics of IDPs, can be obtained from the model logits and embeddings.
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Mutations in the splicing factor SRSF2 are commonly found in healthy individuals with clonal hematopoiesis (CH), where they confer a high annual clonal growth rate and an elevated risk for MDS/AML transformation [ 1 ]. Accordingly, SRSF2 mutations frequently occur in patients with myelodysplastic neoplasms (MDS, 10-15%...
Abstract Luciferases are widely used bioluminescent reporters, yet access to these enzymes has historically relied on recombinant expression. Using automated fast-flow peptide synthesis (AFPS), we synthesized Gaussia luciferase (GLuc, 18.1 kDa, 168 amino acids), picALuc (13 kDa, 120 amino acids), and LuxSit-i (13.8 kDa...
Abstract – Development of a Wound Healing Bioactive Rutin-Enriched Poly-Herbal Hydrogel Matrix: In Silico Mechanism and In Vivo(In Vivo done by Insilico AI) Acceleration of Diabetic Wound Healing Events Background: Diabetic wound pathogenesis involves sustained inflammation, oxidative stress, poor angiogenesis, bacteri...
Epistasis predicted by enzyme-constrained metabolic models is computed at a single value of the protein available to metabolism, although that amount varies two- to three-fold with growth rate. We ask how epistatic interactions are affected by computing every single and pairwise gene deletion in an enzyme-constrained m...
Supplementary single-cell sequencing and protein quantification maps. Supplementary Figure S1. Marker-gene expression across annotated cell types.Dot plot showing representative marker-gene expression across the annotated cell types in GSE135893. Dot size indicates the percentage of cells expressing each gene, whereas...
ESMCHalo is a frozen protein-sequence predictor that combines ESMC-600M layer-36 canonical mean representations with five compact student heads trained using out-of-fold teacher targets with documented cross-fold limitations. The release provides frozen inference code, model checkpoints, calibration, a fixed threshold,...
.A pressing issue in improving traditional frozen meat-and-plant semi-finished products is enhancing their nutritional value through the evidence-based selection of innovative ingredients, while evaluating their nutrient content and protein balance.The aim of this research was to evaluate the nutritional value and amin...
Rab GTPase Y2H Interactome — Verified Hit DatasetThis dataset contains the curated set of protein-protein interactions identified in a yeast two-hybrid (Y2H) screen against 36 human Rab GTPases, each tested in both nucleotide-locked conformations: GTP-bound (constitutively active, Q→L mutant) and GDP-bound (dominant-ne...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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