Background. Type 2 diabetes mellitus (T2DM) is diagnosed at decompensation thresholds — fasting plasma glucose (FPG) ≥126 mg/dL or HbA1c ≥6.5% — that typically declare disease only after substantial β-cell loss. Normoglycemic offspring of parents with T2DM carry several-fold lifetime risk yet receive no structured surv...
Alireza Zare banadkouki· Zenodo (CERN European Organi...· 0 citations
Model code, digitised source data and figure scripts for a forward model of deposit formation in granular corneal dystrophy type 2 (TGFBI R124H), treated as precipitation of a slightly supersaturated protein in a curved, partly non-renewing tissue rather than as a protein-folding disease. The work has no experimental d...
Sejun Kim· Zenodo (CERN European Organi...· 0 citations
Understanding protein folding is crucial for protein sciences. The conformational spaces and energy landscapes of cold (unfolded) protein states, as well as the associated transitions, are hardly explored. Furthermore, it is not known how structure relates to the cooperativity of cold transitions, if cold and heat unfo...
Edward H. Snell, Brian Kuhlman, Lakshmanane Premkumar et al.· UNC Libraries· 0 citations
In summary, loss of qseB disrupts the QseB/QseC system, which affects stress response, metabolism, and cell structure, providing clues for understanding the pathogenic mechanisms of G. parasuis.
Evaluating multi-state structure prediction requires a reference set that can distinguish genuine two-state recovery from a single-fold output that happens to match two similar reference states — and the de facto standard, the 92 experimentally characterized fold-switching proteins on which the field has evaluated sinc...
Zeyuan Ma· Zenodo (CERN European Organi...· 0 citations
The collective data uncover the critical role of D229 in toxin folding and structural dynamics, which in turn impacts toxin potency through effects on the efficiency of PDI-driven toxin disassembly.
F. Kersten, Natalia Mojica, Albert Serrano et al.· ACS Omega· 0 citations
Evaluating multi-state structure prediction requires a reference set that can distinguish genuine two-state recovery from a single-fold output that happens to match two similar reference states — and the de facto standard, the 92 experimentally characterized fold-switching proteins on which the field has evaluated sinc...
Zeyuan Ma· Zenodo (CERN European Organi...· 0 citations
Toxic protein aggregates can accumulate in the cytosol and within organelles of cells when protein quality control machinery fails. Here, we systematically analyzed the consequences of protein aggregation in mitochondria by targeting aggregation-prone proteins to the mitochondrial matrix in Saccharomyces cerevisiae and...
Hauke Holthusen· Universitätsbibliothek der L...· 0 citations
Dysregulated dopamine (DA) signaling and redox homeostasis contributes to multiple neuropsychiatric and neurodegenerative disorders. Polymorphisms that influence the activity of catechol-O-methyltransferase (COMT), an enzyme critical for degrading DA in the dorsolateral prefrontal cortex, have been implicated in behavi...
S. Tripathi, Suwarna Chakraborty, Neil B. Wood et al.· Proceedings of the National...· 0 citations
The archive contains the processed ¹⁵N CEST profiles of WT Im7 recorded at 600, 800 and 1200 MHz at 10 °C and at 800 MHz at 15 and 20 °C, the ¹⁵N TROSY-CPMG profiles recorded at 600 and 800 MHz at 10 °C, and the ChemEx experiment, method and parameter files together with the shell scripts that launched every fit report...
Ved Prakash Tiwari, Laetitia Rožić, Sebastian Hiller· Zenodo (CERN European Organi...· 0 citations
Precisely controlling cell function at the cellular level, rather than through macro‐device interfaces, remains a central challenge for advanced electroceuticals. Here, we report a conductive, protein‐mediated nanoarchitecture in which the bifunctional enzyme dehydroquinate dehydratase/shikimate dehydrogenase (DHQ‐SD...
Viktoriya Pakharenko, D. R. Negrão, Tanmay Gupta et al.· Advanced Functional Material...· 0 citations
The archive contains the processed ¹⁵N CEST profiles of WT Im7 recorded at 600, 800 and 1200 MHz at 10 °C and at 800 MHz at 15 and 20 °C, the ¹⁵N TROSY-CPMG profiles recorded at 600 and 800 MHz at 10 °C, and the ChemEx experiment, method and parameter files together with the shell scripts that launched every fit report...
Ved Prakash Tiwari, Laetitia Rožić, Sebastian Hiller· Zenodo (CERN European Organi...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
