AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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1,975 papers
A proximity biotinylation approach coupled to quantitative mass spectrometry that maps the host-bacterial interface during infection identifies UFMylation as an ancient antibacterial pathway and holds great promise to reveal other cell-autonomous immunity mechanisms.
CRISPR–Cas12a underlies powerful genome-editing and nucleic-acid detection technologies, yet its performance is limited by inefficient target engagement and low catalytic turnover, particularly at low target abundance and elevated temperatures. Here, we report a modular protein-engineering strategy to enhance Cas12a tr...
Integrated proteomic and metabolomic profiling revealed residual lipid-related molecular signatures beyond conventional lipid parameters in patients with PAD undergoing lower-extremity revascularization, supporting further validation of molecular biomarkers for postoperative cardiovascular risk stratification in PAD.
Virtual-screening cascades assembled from co-folding and learned-affinity models are now routine, and each stage is usually trusted on the strength of its own score. We measured, stage by stage, whether those scores carry the information a practitioner would attribute to them, using the Keap1–Nrf2 protein–protein inter...
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Investigations of molecular magnetism, molecular recognition, and the nicotinic acetylcholine receptor are reported. Chapter 2 Studies of the spin state preferences of organic biradicals provide information valuable for the design of molecular magnetic materials. Ab initio calculations on pyridine and pyridinium analog...
It is highlighted that perturbational signatures in the disease-relevant human cell type harbor target-relevant signals beyond human genetics, offering a generalizable route to indication-specific prioritization as perturbation atlases expand.
GHKL ATPases share a unique Bergerat ATP-binding fold and regulate diverse biological processes through ATP-dependent conformational changes. An early step of ATP hydrolysis in this family has been attributed to a single highly conserved glutamate residue proposed to function as the general base. However, mutations of...
The potential of AI-assisted de novo protein design for generating effective Stx-neutralizing proteins is demonstrated and a promising framework for the development of novel therapeutics is established.
Evaluating multi-state structure prediction requires a reference set that can distinguish genuine two-state recovery from a single-fold output that happens to match two similar reference states — and the de facto standard, the 92 experimentally characterized fold-switching proteins on which the field has evaluated sinc...
GHKL ATPases share a unique Bergerat ATP-binding fold and regulate diverse biological processes through ATP-dependent conformational changes. An early step of ATP hydrolysis in this family has been attributed to a single highly conserved glutamate residue proposed to function as the general base. However, mutations of...
Transport of macromolecules between the nucleus and cytoplasm requires a gradient of the small GTPase, Ran. Ran:GTP marks the nucleus because Ran activity requires a cytoplasmic GTPase activating protein (RanGAP) for GTP hydrolysis. As expected for such central and essential cellular machinery, both Ran and RanGAP are...
Background. Type 2 diabetes mellitus (T2DM) is diagnosed at decompensation thresholds — fasting plasma glucose (FPG) ≥126 mg/dL or HbA1c ≥6.5% — that typically declare disease only after substantial β-cell loss. Normoglycemic offspring of parents with T2DM carry several-fold lifetime risk yet receive no structured surv...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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