Background/Objectives: During the 2025–26 influenza season, the antigenically distinct A(H3N2) subclade K emerged and spread globally, raising significant concerns regarding seasonal vaccine effectiveness. This study aimed to map antigenic and structural divergence of this novel strain compared to the 2025/26 A(H3N2) v...
Ital Nemet, N. Zuckerman, N. Atari et al.· Vaccines· 0 citations
The generation of chicken-derived scFv antibodies targeting the FCV VP1-CDEF' region are reported, with high-affinity clones 2B2 and 2E1 are promising candidates for rapid diagnostic test development and warrant further evaluation.
Yan-Quan Wei, Yi-Han Liu, Zhen Han et al.· Frontiers in Microbiology· 0 citations
Center of Lifestyle Medicine, , School of Medicine, University of São Paulo, São Paulo, Brazil Systemic Lupus Erythematosus (SLE) is a heterogeneous autoimmune disease characterized by persistent systemic inflammation, immune complex deposition, and multi-organ involvement. Although major therapeutic advances have succ...
Ulises De la Cruz-Mosso, Karen Pesqueda-Cendejas, Carolina F. Nicoletti et al.· Frontiers in Lupus· 0 citations
Objective
To characterize the timing and between-cow consistency of iron-handling transcript changes after lipopolysaccharide (LPS) exposure in primary bovine monocyte-derived macrophages.
Methods
Macrophages from 5 adult Holstein donor cows were exposed to Escherichia coli LPS or PBS and profiled by RNA sequencing a...
Kevin Hall, Leah Dunston, Donghee Lee et al.· American Journal of Veterina...· 0 citations
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HFYP alleviates exercise-induced fatigue through the synergistic regulation of skeletal muscle lactate metabolism and hepatic lactate-to-glucose recycling via the muscle-liver axis, which provides a solid theoretical basis for the high-value utilization of yeast protein and the development of HFYP-based antifatigue fun...
Xiao-Yu Ma, Lin Li, Quan-Xi Wang et al.· Journal of Agricultural and...· 0 citations
Methanogenic archaea harbor diverse enzymes that support their survival in extreme environments and play key roles in global carbon cycling. The C39 peptidase family, known for cleaving peptide substrates, now gains functional expansion through A0A126R2S0, a novel enzyme that shares structural homology with C39 peptida...
Immune-cold melanomas respond poorly to immune checkpoint blockade (ICB). We assessed whether RNA-seq-based immune subtyping and connectivity mapping could nominate repurposable compounds to shift immune-depleted melanoma toward an immune-enriched phenotype. Using RNA-seq from 432 The Cancer Genome Atlas Skin Cutaneous...
S. Brnić, R. Likić· Melanoma research· 0 citations
The hydrophobic effect is one of the most consequential organizing principles in molecular biology, laying the foundation for explanation of concepts like protein folding, molecular recognition, membrane self-assembly and allosteric communication. Its conceptual description remains dependent primarily on a framework es...
Fusobacterium nucleatum encodes HmuF, which has been shown in vitro to bind tightly to heme, traffic the cofactor to anaerobilin synthase, and catalyze the four-electron reduction of anaerobilin. The structure of the heme-bound HmuF paralog, FldH, reveals an α-helical cap appended to the flavodoxin domain. Molecular...
Stella I. Widjaja, M. Khalilian, Alexandra K. McGregor et al.· Biochemistry· 0 citations
Statistical couplings between protein sites have been enormously useful for protein structure prediction, but there is still debate on the selective forces that generate them. Here we explicitly predict the couplings considering selection for protein folding stability, both against unfolding and misfolding, which we mo...
Fatemeh Saebi, Jonas Minning, U. Bastolla· Journal of Molecular Evoluti...· 0 citations
Transmembrane proteins participate in numerous cellular processes, but their investigation is complicated by the compositional complexity of biological membranes. In particular, G protein-coupled receptors, which represent targets for nearly 50% of pharmaceuticals, require well-defined model membrane systems for functi...
Izabella Brand, Maxmilian Skoda, Mr Patryk Bielski et al.· Science and Technology Facil...· 0 citations
The folding of newly synthesized proteins is assisted by an essential network of proteins known as molecular chaperones. In bacteria, the chaperones Trigger Factor (TF), DnaK/DnaJ (Hsp70 system), and GroEL/GroES (chaperonin system) are key players in proteostasis maintenance. Here, we further explore the cooperation an...
Marie-Pierre Castanié-Cornet, Tatsuya Niwa, É. Dupuy et al.· Proceedings of the National...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
