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1,959 papers
Findings identify SFRP2 as a key regulator of PDAC progression and support the development of SFRP2-targeted therapies as a novel treatment strategy for pancreatic cancer.
Carfentanil, an ultrapotent synthetic opioid, poses a severe public health threat because of its rapid brain penetration and potent activation of μ-opioid receptors. Conventional anti-drug vaccines are limited by the poor hapten immunogenicity and dominant anti-carrier immunity. Here, we report a molecularly encoded...
ProteoScopeR is an R package and Shiny application that connects decisions in a traceable workflow and complements downstream exploration in xOmicsShiny and describes sensitivity to analytical choices rather than identify a universally superior method.
Biological membranes are not passive barriers, but chemically heterogeneous and physically adaptable interfaces that regulate how proteins and peptides bind, fold, assemble, and act. Many membrane-active systems cannot be adequately described as simply soluble, peripheral, or transmembrane. Instead, they populate mul...
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Data behind LIVIA cLIP Atlas: AlphaFold-Multimer protein interaction screens scored with iLIS (AFM-LIS), keeping the interface and contact residues of every prediction. livia-atlas-human-proteome.zip: human proteome-wide screen. Schmid et al. (2025), doi:10.1101/2025.11.10.687652. livia-atlas-human-kinase-tf.zip: human...
ENG:Article 4 of the Panchondriome Project (v3.5.2-PRODUCTION) delivers a rigorous biophysical and mathematical synthesis, unifying the large-scale bioelectric tissue codes pioneered by Michael Levin’s laboratory with the classical autowave mechanochemistry of embryonic cell sheets established by B. N. Belintsev. The p...
As the allergens of Haliotis discus hannai (HDH) and their role in human allergy remain limited, we employed an integrated multi-omics strategy combining transcriptome assembly, genome-guided proteogenomics, and quantitative proteomics to systematically profile its allergens, followed by immunobinding assays with aller...
Cyanobacterial blooms are increasingly managed through large-scale mechanical harvesting, but greenhouse gas (GHG) production from moisture-rich cyanobacterial sludge (CS) remains poorly constrained. We conducted two controlled experiments using natural cyanobacterial biomass and harvested CS from Lake Dianchi, a hyper...
This study evaluated how foliar application of sodium nitroprusside (SNP), salicylic acid (SA), and simvastatin (SIM) applied singly and in all pairwise combinations, affects the growth, leaf anatomy, biochemistry, and essential-oil profile of greenhouse-grown Thymus vulgaris L. SNP + SA produced the most pronounced ve...
Overall, SARS-CoV-2 Mpro evolution is strongly constrained by structural and functional requirements, supporting the suitability of this protein as an effective antiviral target and suggesting that incorporating viral evolutionary dynamics may help inform the design of therapeutic strategies with improved long-term rob...
Findings show that the late phase of podocyte-driven CKD involves distributed protein-level remodelling, including an RNA-discordant increase in NR3C2 protein and a candidate plasma-protein-handling signature.
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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