Ulcerative colitis (UC) is a chronic mucosal immune disorder in which 30-50% of patients fail biologic therapy, yet the full-thickness immune architecture of medically refractory disease and reliable tissue-level markers of treatment response remain undefined.
Using 10x Visium HD spatial transcriptomics (16-...
Qing-Quan Bai, Run-Yang Li, Zheng-Jin Liu et al.· Frontiers in Immunology· 0 citations
Neurons rely on precise protein folding, trafficking, and turnover to maintain synaptic function. Disruption of proteostasis promotes misfolded proteins that impair axonal transport, mitochondrial function, and signalling, contributing to neuronal loss. Although neurodegeneration has traditionally focused on stable amy...
Suelen Camargo, Kevin Novelo, Scott D. Ryan· Frontiers in Molecular Neuro...· 0 citations
================================================================================ Duqueana Core - p53 Structural Restoration Analysis v1.0.0 Detección Determinista de Ángulo de Ruptura y Vector de Restauración ================================================================================ Autor: Douglas Helvesio Urbina...
Douglas Helvesio Urbina Duque· Zenodo (CERN European Organi...· 0 citations
Aromatic amino acids buried inside folded proteins play a critical role in stabilizing both the folded conformation and anchoring incoming substrate molecules. Moreover, their ring flips serve as sensitive probes of protein breathing motions. In this work, we accurately estimate the ring-flip rates of a phenylalanine...
Bikirna Roy, Arnab Mukherjee· Journal of Physical Chemistr...· 0 citations
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P-glycoprotein (P-gp), a key efflux drug transporter which plays a pivotal role in the in vivo pharmacokinetics of medications, undergoes alterations in expression and function following radiation exposure that can impact drug metabolism and therapeutic efficacy. Current research has found that clinical doses of radiat...
Hai-Yang Wu, Jing Yang, Run-Tian Li et al.· International Journal of Mol...· 0 citations
GHKL ATPases share a unique Bergerat ATP-binding fold and regulate diverse biological processes through ATP-dependent conformational changes. An early step of ATP hydrolysis in this family has been attributed to a single highly conserved glutamate residue proposed to function as the general base. However, mutations of...
Kenji Fukui, Ayaka Shibuya, T. Murakawa et al.· eLife· 0 citations
Infection susceptibility and severity in the UK Biobank proteome Analysis notebook accompanying "The Frailty Proteome Predicts Infection Admission,\\but Only Weakly Predicts Survival" (Jacobs). It reproduces every number in the manuscript from the inputs described below and writes all exports to ./infect_out/. What it...
Laurence A Jacobs· Zenodo (CERN European Organi...· 0 citations
A covalent fragment-based approach was used to develop IDH1-C269 selective inhibitors which prevent the key regulatory segment from forming an α-helix required for catalytic competency, and provide structurally validated inhibitors for further development.
Charles P. Brown, Elliot O. Harmer, Ariba Azam et al.· bioRxiv· 0 citations
It is shown that RcsF and RcsD exhibit strong co-evolutionary coupling independent of host speciation, and co-evolution of an auxiliary protein generates novel regulatory function in the Rcs phosphorelay and provide insights into the role of RcsD periplasmic domain in stress signal transduction.
Abdelraouf O. Dapour, Moustafa Shehata, R. Siam et al.· PLoS ONE· 0 citations
Chinese hamster ovary cells (CHO) are the main platform for monoclonal antibody production in the growing biopharmaceutical market. Compared to other production platforms, CHO cells, being mammalian cells, have the major benefit of providing appropriate protein folding and glycosylation patterns. However, further knowl...
D. Stoyanova· University of Edinburgh· 0 citations
Yak colostrum is crucial for the adaptation of newborn calves to the harsh environment of the Qinghai–Tibet Plateau. However, the modulation of its bioactive components along altitudinal gradients and the molecular basis remains incompletely understood. This study evaluated the bioactive components including immune fac...
Rong-Fu Song, Mei Du, Sheng-Rong Chen et al.· Agriculture· 0 citations
Understanding how positive selection shapes molecular evolution at the protein level remains a major challenge, particularly in non-model species. Here, we integrated phylogenetic evidence from candidate genes evolving under lineage-specific positive selection with comparative structural and biophysical analyses to inv...
Danilo T. Amaral, João Alfredo Teodo, M. I. O. Cardoso et al.· Genetica· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
