protein folding

Punicalin targets RSV glycoprotein and fusion protein at non-overlapping sites to prevent viral escape.

In RSV-infected mice, nebulized PUN provides sustained respiratory exposure, reduces lung viral loads and pathology, and attenuates inflammatory responses, and in RSV-infected mice, nebulized PUN provides sustained respiratory exposure, reduces lung viral loads and pathology, and attenuates inflammatory responses.

A clinical decision support framework for automated M-protein isotype classification from capillary zone electrophoresis immunotyping signals.

This study presents the first ML-based CDS framework for M-protein isotype classification from CZE-IT signals, demonstrating that uncertainty-aware design can identify 62% of samples as eligible for automation-assisted verification while routing lower-confidence cases to expert review through confidence-based triaging...

Modest Changes in Extracellular pH Impose Metabolic and Envelope Remodeling in Burkholderia thailandensis.

The relative proteomes for cells exposed to a change in pH from 7.0 to either 6.0 or 8.0 are reported to afford insight into how B. thailandensis responds to physiologically relevant pH changes to achieve optimal niche adaptation, survival, and competitive fitness.

Integrative transcriptomics–metabolomics reveals sphingolipid metabolic reprogramming in traditional Chinese medicine syndrome differentiation of rheumatoid arthritis

C17-sphinganine is a core metabolic biomarker for distinguishing kidney-liver deficiency syndrome from heat-dampness syndrome, enabling precise syndrome classification with a single measurement.

Structural and Functional Diversity of Serine Protease-Like DEG (Degradation of periplasmic proteins) Genes in Potato (Solanum tuberosum L.)

A comprehensive genome-wide analysis identified 19 serine protease-like DEG family proteins in potato, revealing their structural diversity, domain architecture, and regulatory potential and highlighting the functional versatility of DEG proteases in potato development and stress adaptation.

Microbial production of eumelanin from a desert-derived Aspergillus terreus: statistical optimization, comprehensive characterization, and in silico insights into breast cancer-associated targets

The combined experimental and computational findings support the potential of the produced eumelanin for future breast cancer-related investigations, and establish a desert-derived A. terreus isolate as a promising microbial cell factory for eumelanin production through statistical optimization and comprehensive struct...

LoGoPPI enables fast and accurate protein–protein interaction mapping at scale

LoGoPPI is presented, which infers PPIs from sequence by combining bi-encoder global protein representation with local residue-level late interaction, and provides a scalable framework for comparative and functional analysis of protein networks across diverse taxa.

Class-specific cysteine folding sensitivity in protein language models: evidence from iron–sulfur and disulfide-rich proteins

LIVIA Atlas: AlphaFold-Multimer protein interaction screens resolved to residues

Data behind LIVIA cLIP Atlas: AlphaFold-Multimer protein interaction screens scored with iLIS (AFM-LIS), keeping the interface and contact residues of every prediction. livia-atlas-human-proteome.zip: human proteome-wide screen. Schmid et al. (2025), doi:10.1101/2025.11.10.687652. livia-atlas-human-kinase-tf.zip: human...

Evidence of P-glycoprotein mediated bidirectional transport of beta-amyloid (Ab40 and Ab42) through CLEFF4 cells

Integrated Multi-Omics Analysis Reveals Molecular Signatures Associated with Growth Divergence in Mandarin Fish (Siniperca chuatsi)

The cross-sectional extreme-phenotype design identifies molecular signatures associated with the observed growth phenotype without establishing causality within-cohort growth heterogeneity in aquaculture productivity.

Abstract B052: Understanding latent resistance mechanisms and their phenotypes in pancreatic cancer organoids under KRASG12D inhibition

The rate of acquired resistance to Zoldonrasib was found to be rapid in PCO models and independent of EGF stimulation, and opposing signaling pathway activation in resistant PCOs to Zoldonrasib at 200nM dependent upon EGF stimulation was suggested.