Resveratrol enhances MTX’s anti-inflammatory effects via dual inhibition of NF-κB and MAPK pathways, while reducing MTX-induced toxicity, and support the potential of MTX-resveratrol co-therapy as a safer, more effective strategy for managing chronic inflammatory diseases.
Mashael J. Abu-Alola, Moonerah M. Alnasser, A. Al-Qahtani et al.· Journal of King Saud Univers...· 0 citations
The RNA recognition motif (RRM) domain of TAF15 protein plays an essential role in RNA binding and regulation of diverse cellular processes. However, the molecular mechanism underlying its structural stability and folding behaviour associated with disease state remains poorly understood. Herein, we performed an extensi...
Photocurable recombinant proteins and engineered polypeptides offer sequence-level control that is unavailable in most natural extracts or synthetic polymers. That control is meaningful only if molecular identity, folding state, functionalisation and network formation remain traceable through processing. Chemical modif...
Juan Segurola· Zenodo (CERN European Organi...· 0 citations
It is proposed that TMEM263 can interact with and support the condensation of neutral lipids in a bilayer to promote lipid droplet formation and growth and provide a mechanistic understanding linking these phenotypes to impaired lipid droplet biology.
Katy Yalci, N. Chala, Joanna J. Moss et al.· Nature Communications· 0 citations
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This paper presents a complete symbolic proof of the Collatz Conjecture using the Expansion–Compaction–Torsion (ECT) model. By interpreting the iterative Collatz function as a symbolic parity-driven oscillator, the authors define a torsion-based energy function δ(n) that tracks the expansion (odd steps) and compaction...
Andrew Robert Hutchins, Helen Christina Hutchins, Nova Freeman Wells· Zenodo (CERN European Organi...· 0 citations
Photocurable recombinant proteins and engineered polypeptides offer sequence-level control that is unavailable in most natural extracts or synthetic polymers. That control is meaningful only if molecular identity, folding state, functionalisation and network formation remain traceable through processing. Chemical modif...
Juan Segurola· Zenodo (CERN European Organi...· 0 citations
It is said that when the liver weakens, drugs act too strongly. What this paper shows is that the same change in the liver acts differently on an injection and on a pill, and that for a drug the liver removes almost completely (high extraction ratio) the injection is governed by liver blood flow and the pill by the liv...
Yuuki Yamagishi· Zenodo (CERN European Organi...· 0 citations
Structural analyses indicated that OsFe2200 adopts a putative Kelch β-propeller-like fold, while additional structural comparisons identified β-propeller- and Kelch-like proteins as moderate confidence homologs, suggesting that OsFe2200 is a structurally conserved but sequence divergent protein.
Reversible covalent targeting of cysteine residues offers a powerful strategy for generating potent and tunable ligands, but designing electrophiles with balanced reactivity, stability, and reversible binding remains challenging. Here, we systematically optimized reversible α,β-unsaturated nitrile electrophiles and i...
Yu-Qian Zhang, Meng-Zhu Qi, Xian-Kai Liu et al.· Journal of the American Chem...· 0 citations
Honey bees (Apis mellifera) are highly sensitive to environmental stressors, including gamma radiation. We evaluated the biochemical responses of adult worker bees to graded gamma-irradiation doses (20, 30, 40 and 50 rad). Total soluble protein content and the activities of key enzymes; superoxide dismutase (SOD), cata...
Mohamed M. Abdel-Monsef, Sameh G. Sawires, Doaa A. Darwish· Entomological News· 0 citations
Protein folding is a process in which the linear amino acid chain is transformed into a stable three-dimensional native structure which enables the protein to carry out its function. In several neurodegenerative diseases, including Alzheimer's disease (amyloid-β) and Huntington's disease (huntingtin), a pathological me...
Yi-Yuan Xie· Theoretical and Natural Scie...· 0 citations
This work proves equivalence to the dense recurrence in real arithmetic, under an explicit scalar branch-interface assumption, and applies candidate sparsification to the multiloop recurrence of a Turner~2004 dangle-0 solver over a weighted codon automaton.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
