Structural models of the quaternary complex comprising the heterotrimeric PP2A holoenzyme and the phosphorylated Parkin Ubl domain were generated using AlphaFold3. The modeled protein assembly included the catalytic subunit Cα (PP2Ac, Uniprot: P67775), the scaffolding subunit PR65A (residues 1–589, Uniprot: P30153), th...
Chun Tang, Fuxiang Liang, Lingsen Meng· Zenodo (CERN European Organi...· 0 citations
Findings demonstrate that the indigenous A. vinelandii strain AztACU1 possesses multifunctional plant growth-promoting traits and effectively enhances salinity tolerance in rice, highlighting its potential as a sustainable biofertiliser for improving productivity in salt-affected agroecosystems.
Abhilipsa Ayesha, Mishra Swetaleena, K. S. Chinmaya et al.· Plant Science Today· 0 citations
It is shown that evolutionary changes in CCNB1IP1 expression have contributed to the enlargement and folding of the primate cortex and that a CCNB1IP1 knock-in can develop cortical folding in otherwise smooth mouse brains.
Ting Hu, Peng-Cheng Ma, Yi-Fan Kong et al.· Nature Genetics· 0 citations
The protein folding problem, characterized by Levinthal’s paradox, complex energy funnels, and co-translational kinetic trapping, is fundamentally unified within the Seonggil Matrix Theory (SMT) and Rough Operator Algebra (ROA). By redefining the conformational search space as a topological phase separation guided by t...
Seonggil Lee· Zenodo (CERN European Organi...· 0 citations
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Modern geroscience celebrates marginal increments in chronological life expectancy while overlooking a catastrophic structural failure: the global healthspan-lifespan gap has widened to 9.6–12.4 years of chronic morbidity, disability, and biological decline. Despite hundreds of billions invested into downstream senolyt...
Viktor Z. Dyment, Diane Smolyar, Glen Rein· Zenodo (CERN European Organi...· 0 citations
Significantly increased postoperative serum NLRP3 levels are independently associated with POD in elderly patients with lung cancer, and the model integrating serum NLRP3 levels shows favorable predictive performance for POD.
Yuan-Chao Cheng, Yu-Zhe Liu, Guang-Lin Tan et al.· Frontiers in Neurology· 0 citations
An inflammatory response in leukocytes due to the increase in genes related to eosinophil and potential macrophage production, and along with an increase in antioxidant genes, indicate elevated OS in derm dogs.
Selena K. Tavener, Dayakar L. Badri, K. Panickar· Journal of Animal Science· 0 citations
The protein folding problem, characterized by Levinthal’s paradox, complex energy funnels, and co-translational kinetic trapping, is fundamentally unified within the Seonggil Matrix Theory (SMT) and Rough Operator Algebra (ROA). By redefining the conformational search space as a topological phase separation guided by t...
Seonggil Lee· Zenodo (CERN European Organi...· 0 citations
This work redefines the cell membrane beyond the classical fluid mosaic model into a coherent biophotonic network. Every membrane constituent—including lipids (PC, PE, PS, PI, SM, cholesterol), integral and peripheral proteins, ion channels, pumps, receptors, HLA molecules, glycocalyx, cytoskeleton, lipid rafts, and ex...
outail benhadid· Zenodo (CERN European Organi...· 0 citations
Acrolein (ACR) and glyoxal (GO) are highly reactive carbonyls originating from endogenous metabolism, environmental pollution, and thermal food processing. This study compares the toxic mechanisms and redox effects of a 24 h exposure to ACR (30, 60, 90 µM) and GO (2, 5, 10 mM) in PBMCs. We assessed cell viability, lipi...
Michal Kopera, Malgorzata Adamkiewicz, Joanna Bernasińska-Słomczewska et al.· International Journal of Mol...· 0 citations
ABSTRACT Viral infection often induces chlorosis, a symptom closely associated with chlorophyll (Chl) degradation. STAY‐GREEN (SGR) proteins are key regulators of Chl breakdown, but their roles in plant virus resistance remain poorly understood. In this study, we identified six NtSGR family genes in Nicotiana tabacum a...
Ming Gu, Ke-Xin Cao, Jia-Min Yu et al.· Molecular plant pathology· 0 citations
A novel calcium-chelating peptide, KTFQGPPHG, was identified and screened from Moringa oleifera Lam. leaf protein hydrolysate, and further used to prepare a highly stable peptide–calcium chelate (KTFQGPPHG-Ca). The structure of KTFQGPPHG-Ca was characterized, while assessing its chelation stability and calcium transpor...
Rui-Jing Gu, Xin-Yu Wang, Zi-Lin Wang et al.· Foods· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
