protein folding

Design, Synthesis, and Evaluation of Novel Cephalotaxine-Cinnamic Acid Derivatives Against Hepatocellular Carcinoma

Cephalotaxine (1) is a parent compound within the cephalotaxine alkaloids class mainly derived from Cephalotaxus plants. In this study, by coupling 1 with cinnamic acid, 17 novel cephalotaxine-cinnamic acid derivatives (S1–S17) were designed and synthesized to enhance their anti-tumor efficacy. Among them, S10 showed t...

Endothelial Proteotoxic Stress Drives Inhaled Benzene-Induced Vascular Inflammation in Mice.

Benzene exposure is associated with increased cardiovascular disease (CVD) risk, yet the mechanisms linking benzene to vascular injury remain incompletely understood. Here, we investigated the effects of benzene and its reactive metabolite trans,trans-muconaldehyde (MA) on endothelial activation and leukocyte recruitme...

Structural Analysis of NR1H3 Variants (R415Q, P199H, S440C) Reveals Residue-Specific Grounding for RXR-Interface Disruption in Familial Multiple Sclerosis (MS)

Familial Multiple Sclerosis (MS) has been proposed to exhibit a biological association with the R415Q mutation in the Liver X Receptor Alpha (LXRA) protein, in which the subsequent localized discrepancies on the protein's structure are alleged to disrupt heterodimerization (Salles, in review). Unlike R415Q, other NR1H3...

Structural Analysis of NR1H3 Variants (R415Q, P199H, S440C) Reveals Residue-Specific Grounding for RXR-Interface Disruption in Familial Multiple Sclerosis (MS)

Familial Multiple Sclerosis (MS) has been proposed to exhibit a biological association with the R415Q mutation in the Liver X Receptor Alpha (LXRA) protein, in which the subsequent localized discrepancies on the protein's structure are alleged to disrupt heterodimerization (Salles, in review). Unlike R415Q, other NR1H3...

Cytokine-induced nuclear translocation of STAT1 via a non-transferable NLS

The targeting function of nuclear localization signals (NLSs) is generally considered independent of a protein's native sequence or fold and is readily transferable to heterologous cargos. Contrary to this paradigm, rapid nuclear translocation of phosphorylated STAT1 (pSTAT1) following cytokine stimulation requires imp...

Differential analysis of pulmonary smooth muscle cells vs aortic smooth muscle cells

This dataset provides paired transcriptomic (RNA-seq) and proteomic profiling of vascular smooth muscle cells (VSMCs) from pulmonary artery and aorta under hypertensive and normotensive conditions in rats, aiming to identify tissue-specific molecular responses to hypertension. Four groups (n=3 each): NPA (normal pulmon...

PS5-9. Dietary Ginger Root Extract Modulates Intestinal Antimicrobial Peptides and Redox Proteins in Salmonella Infected Broiler Chicks.

Salmonella infection remains a major challenge in antibiotic-free poultry production, highlighting the need for alternative dietary strategies that support intestinal immune responses and oxidative stress defense. This study evaluated the effect of dietary ginger root extract (GRE) in modulating intestinal antimicrob...

PS2-21. Effect of Ile, Leu, and Met and Insulinemic Energy Supplementation on Mammary Gland and Muscle Gene Expression.

We aimed to investigate the effect of insulinemic energy source (ES) with AA supplementation on mammary and muscle gene expression differences in lactating cows. Rumen-cannulated, multiparous Holstein cows (70±26 DIM, n = 16) were enrolled in a replicated 4x4 Latin square study with 21-d periods and treatments arrang...

E8 Phi-Lattice as Quantum Consciousness Coupler — E8 Intelligence Research

Using the 240 E8 root vectors as a dynamic phase‑modulation scaffold, we demonstrate that phi‑coupled 132 Hz inputs can generate a self‑synchronizing attractor field that links quantum superposition lifetimes to neural oscillation phases. This field produces a stable interference pattern that simultaneously modulates p...

De novo design of protein antagonists of bacterial pathogen type III secretion system needle assembly

The rational design and characterization of functional T3SS needle binding proteins are reported, establishing a molecular blueprint for the design of functional T3SS needle binding proteins, enabling future efforts to disrupt conserved secretion systems underlying bacterial pathogenesis.

Session 7: Protein Folding and Degradation in Aging and Disease (joint session)

CTL1 (SLC44A1) regulates myelin lipid composition and architecture in Schwann cells

Myelin formation requires extensive membrane lipid synthesis, yet how myelinating glia acquire the choline needed for this process remains incompletely understood. Choline transporter-like protein 1 (CTL1; SLC44A1) is highly expressed in Schwann cells, and CTL1 deficiency in oligodendrocytes impairs CNS myelination. He...