Longevity medicine needs ways to identify a small number of candidate intervention targets that might affect several functions at once. Protein–protein interaction (PPI) networks help map molecular connections and rank candidate drugs, but they do not show which maintenance states are associated with age-related patter...
Cucurbit powdery mildew (CPM) and Cucurbit yellow stunting disorder virus (CYSDV) are major constraints to sustainable melon (Cucumis melo L.) production worldwide. To elucidate the genetic basis of resistance and accelerate breeding, we integrated genome-wide association studies (GWASs), transcriptome validation, and...
Krishna Sai Karnatam, Roopa Sowjanya Potlannagari, Carlos E. Ortíz et al.· Plants· 0 citations
While the roles of classical type 2 (T2) inflammatory factors in allergic rhinitis (AR) have been well characterized, the roles of non-classical T2 inflammation factors are less explored. This study aimed to elucidate the roles and predictive significance of non-classical T2 inflammatory factors in AR.
AR-re...
Ying-Tong He, Bei-Rong Liu, Xue-Gui Liu et al.· Frontiers in Immunology· 0 citations
The detection of soluble amyloid-β (Aβ), the most neurotoxic species in early Alzheimer's disease (AD), remains a major analytical challenge. Conventional probes are designed to target the β-sheet structures of mature fibrils and are thus blind to these transient, nonfibrillar species. Here, we introduce "site-ordered...
Rui-Long Dai, Jian-Feng Dai, Chen-Xu Yan et al.· Angewandte Chemie· 0 citations
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To the Editor,We read with interest the study titled "Expression of miR-101-3p and its target ADAM15 gene in colorectal cancer patients" published in the Çukurova Medical Journal . The authors' study is significant in that it draws attention to the potential relationship between miR-101-3p and ADAM15 in colorectal canc...
O. Alkan, I. Nazli, Ahmet Başgöze· Cukurova Medical Journal· 0 citations
Dataset Title: Refined Coordinate Structures and Pocket Analyses for Renal Pathologies and Viral Entry Glycoproteins (v3.0) Overview: Fully quality-controlled 3D structural models, geometric pocket analyses, DiffDock docking enrichment, and NIH NCBI cross-validated target records for 4 therapeutic targets in this disea...
James Paul Trageser· Zenodo (CERN European Organi...· 0 citations
Microbial protein (MP) is a promising alternative protein source that can be produced using methane as a substrate derived from undervalued resources.
Methylococcus capsulatus
is one of the most prominent microbial species employed for industrial production, while other potentially suitable methanotrophs remain...
F. Kerckhof, Norah Benmeridja, K. Rabaey et al.· Frontiers in Chemical Engine...· 0 citations
Dataset Title: Refined Coordinate Structures and Pocket Analyses for Immunology and Autoimmune Disease Targets (v3.0) Overview: Fully quality-controlled 3D structural models, geometric pocket analyses, DiffDock docking enrichment, and NIH NCBI cross-validated target records for 7 therapeutic targets in this disease are...
James Paul Trageser· Zenodo (CERN European Organi...· 0 citations
Dataset Title: Refined Coordinate Structures and Pocket Analyses for Diabetes and Metabolic Disease Targets (v3.0) Overview: Fully quality-controlled 3D structural models, geometric pocket analyses, DiffDock docking enrichment, and NIH NCBI cross-validated target records for 11 therapeutic targets in this disease area:...
James Paul Trageser· Zenodo (CERN European Organi...· 0 citations
Dataset Title: Refined Coordinate Structures and Pocket Analyses for Somatic Cancer Mutations (v3.0) Overview: Fully quality-controlled 3D structural models, geometric pocket analyses, DiffDock docking enrichment, and NIH NCBI cross-validated target records for 8 therapeutic targets in this disease area: BRAF, BRCA1, B...
James Paul Trageser· Zenodo (CERN European Organi...· 0 citations
The increasing demand for sustainable protein sources has stimulated growing scientific interest in edible insects as a promising component of future food systems. This study aimed to map the global research landscape and thematic development of edible insect-based product research. A bibliometric analysis was conducte...
Dewi Anggraini, Eny Palupi, Irma Isnafia Arief et al.· Insects· 0 citations
Purpose: This study aimed to investigate the protective effects of Aronia melanocarpa (chokeberry) seed oil (ASO) against doxorubicin (DOX)-induced cardiotoxicity in H9c2 cells by evaluating apoptosis-related mRNA expression and assessing the potential interactions of ASO-derived fatty acids with apoptosis-related prot...
Sedat Gökmen, F. M. Benli, Irfan Cinar et al.· Cukurova Medical Journal· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
