Lyme disease, caused by the spirochetal bacterium Borrelia burgdorferi, remains the most prevalent vector-borne illness in humans. Addressing challenges such as antibiotic resistance, persistent infection, and complex disease dynamics requires identifying novel therapeutic targets. Manganese (Mn²˖) is essential for the...
Raja Massoud Ali Alawar· Research Portal (Queen's Uni...· 0 citations
Background: Young children are at high risk of serious bacterial infection (SBI), yet rapidly distinguishing bacterial from viral illness in febrile emergency presentations remains challenging. Current biomarkers, including C-reactive protein (CRP) and procalcitonin (PCT), have limited diagnostic performance, contribut...
Acquiring new cellular states entails metabolic reprogramming driven by changes in the expression of cytosolic and mitochondrial metabolic enzymes. Most mitochondrial proteins are synthesized in the cytosol and imported into the mitochondria in a linear form, after which they are folded by a network of mitochondrial ch...
Shani Gabbay, Hila Ben-David, Shatha S. Alassam et al.· Philosophical Transactions o...· 0 citations
Introduction: Diabetic kidney disease (DKD) is a progressive microvascular complication that leads to a decline in renal function and is the most frequent cause of end-stage renal disease. Currently, there is a need for improved biomarkers for the early detection of DKD. microRNAs (miRNAs) are short, non-coding regulat...
Jinnan Zang· Research Portal (Queen's Uni...· 0 citations
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Diabetes is becoming an epidemic disease of global proportions with an estimated 422 million people living with the condition. Cardiovascular diseases (CVD) are the leading cause of death globally with the incidence three-fold higher in people with diabetes. Furthermore, cardiovascular complication of pregnancy, pre-ec...
Abdelrahim M. Alqudah· Research Portal (Queen's Uni...· 0 citations
Chiral amines are valuable intermediates in the pharmaceutical industry, but their synthesis by chemical means has a number of drawbacks,including the need for toxictransition metal catalysts, volatile organic compounds (VOCs), and a lack of stereoselectivity in a singlestep.Increasingly,biocatalysis has been viewed as...
Stephen A. Kelly· Research Portal (Queen's Uni...· 0 citations
A conjectural framework for biological organization spanning molecular to ecosystem scales, organized around thermodynamic game theory and the Maximum Entropy Production Principle (MEPP). The paper examines whether many biological stability problems can be modeled as dissipative structures whose attractors admit Nash-s...
Lukas Geiger· Zenodo (CERN European Organi...· 11 citations
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome marked by inflammation, immune dysregulation, and myocardial fibrosis. Whether pyroptosis intersects with fibrotic remodeling in HFpEF remains uncertain. Two murine cardiac transcriptomic datasets were integrated after batch correction...
Bo-Xu Gao, Gang Wang, Zhi-Qiang Xu et al.· Frontiers in Immunology· 0 citations
High hydrostatic pressure provides a unique and sensitive perturbation to protein structure, enabling direct measurement of volume changes associated with folding, misfolding, and assembly. Because pressure perturbs noncovalent forces while preserving covalent integrity, it reveals conformational intermediates that o...
J. L. Silva, G. C. de Andrade, M. A. Marques et al.· ACS Applied Polymer Material...· 0 citations
A substantial fraction of human proteins have no described function. C17orf58 (UniProt Q2M2W7; "UPF0450 protein C17orf58") is one of them: it has no experimental structure and no functional literature. Here I report a computational characterization of C17orf58 that combines structure prediction, structural homology sea...
Aayush Shah· Zenodo (CERN European Organi...· 0 citations
A substantial fraction of human proteins have no described function. C17orf58 (UniProt Q2M2W7; "UPF0450 protein C17orf58") is one of them: it has no experimental structure and no functional literature. Here I report a computational characterization of C17orf58 that combines structure prediction, structural homology sea...
Aayush Shah· Zenodo (CERN European Organi...· 0 citations
Previously, we reported ITE-derived bioisostere 2-(1
H
-indole-3-carbonyl)-N-methyl thiazole-4-carboxamide (ITE-CONHCH
3
) as a high-affinity ligand and potent agonist of the aryl hydrocarbon receptor (AhR) with anti-colitis properties. In the current study, we present its initial
in vitro
pharmacological profi...
Zdeněk Dvořák, Aneta Grycová, R. Vrzal et al.· Frontiers in Pharmacology· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
