The results suggest that high protein intake in P. ornatus does not increase catabolism of dietary protein but stimulates protein synthesis leading to reduced protein turnover and more energy efficient growth, demonstrating the importance of whole-body protein turnover to nutritional physiology and bioenergetics for op...
Trystan B. Sanders, M. B. Codabaccus, Andrea Williamson et al.· Journal of Experimental Biol...· 0 citations
OBJECTIVE
Pregnancy produces physiologic adaptations that may affect laryngeal tissues, respiratory support for phonation, and voice quality. We performed a scoping review exploring the influence of pregnancy on voice and laryngeal outcomes.
DATA SOURCES
PubMed, CINAHL, and Web of Science.
REVIEW METHODS
A scoping...
John M. Boyd, Jack T. Williams, R. McGowan et al.· The Laryngoscope· 0 citations
The symbiotic skin bacterium Staphylococcus epidermidis moisturizes human skin, contributes to protection against external pathogens, and supports innate immune stimulation. However, the interaction between collagen, a major skin protein, and S. epidermidis remains insufficiently explored. In this study, biofilm develo...
It is demonstrated that CID systems can be used as building blocks for higher-order ligand-controlled protein systems and established a generalisable strategy for harnessing the affinity gains of intramolecular CID systems to create gain-of-signal assays for small molecules and ions.
Zhen-Ling Cui, Zhong Guo, Y. Liew et al.· Angewandte Chemie· 0 citations
Reach audiences
Advertise in front of researchers, engineers, and readers.
Environmental heat stress is an emerging ecological problem, yet the physiological mechanisms linking repeated heat exposure to cardiovascular disease risk remain incompletely understood. Here, we investigated the systemic, cardiovascular, metabolic, and immune consequences of intermittent environmental heat stress. C5...
Hibah Husain, Samantha A. McFall, M. Malovichko et al.· The FASEB Journal· 0 citations
It is demonstrated that mutations in dfrA coding and upstream regulatory regions contribute to para-aminosalicylic acid resistance in Mtb clinical isolates by integrating genomic analysis with functional assays of thermal stability, promoter activity and drug susceptibility.
Rong Zeng, Najeeb Ullah, Jing Gu et al.· JAC-Antimicrobial Resistance· 0 citations
In donor-derived models, THBS1 knockdown in NLM cells reduced area-confluence trajectories, increased migration, and decreased collagen-rich matrix in 4-week spheroids, whereas THBS1 overexpression in DLM cells produced reciprocal changes; aggrecan was not consistently altered.
Shun-Jie Yang, Chen Hou, Hui Wang et al.· Frontiers in Cell and Develo...· 0 citations
Background: Visceral leishmaniasis caused by Leishmania donovani still depends on a small group of drugs whose value is diminished by toxicity, cost and resistance, so targets specific to the parasite remain attractive. The cytoplasmic poly(A)-binding protein (PABP) of Leishmania governs mRNA stability and translation,...
Haimn Abdulbassit Tawfiq, Ahmed Ali Mohammed, Yassir Mustafa Al Mulla Hummadi et al.· Al Mustansiriyah Journal of...· 0 citations
The study of macromolecular assembly formation is one of the most challenging tasks in computational modeling as it requires extensive exploration of conformational and configurational space, especially when driven by conformational transitions or folding instabilities, which are typically associated with high energy...
Margherita Bini, Valentina Tozzini· Frontiers in Molecular Biosc...· 0 citations
Protein engineering has evolved from modifying naturally occurring proteins toward modular, computational, and AI-assisted approaches for designing new molecular functions. Chimeric and fusion protein engineering has demonstrated that functional elements from different proteins can be reorganized into novel architectur...
The outstanding research questions of our BAG (encompassing 9 PIs) focus on proteins and their complexes involved in a variety of processes, ranging from cell homeostasis (from gene regulation to folding quality control, from energy metabolism to signal transduction) to communication and surface recognition (including...
Federico Forneris, Francesca Gasparini, Andrea Gottinger et al.· European Synchrotron Radiati...· 0 citations
Dengue virus (DENV) infection can result in outcomes ranging from subclinical disease to life-threatening illness, yet the antibody features mediating protection in humans remain poorly defined. Dengue virus envelope protein (E) forms homodimers on the virion surface and elicits both neutralizing and non-neutralizing a...
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
