protein folding

Systemic Inflammation and Colorectal Cancer: Assessing the Role of Reverse Causality

Background/Objectives: Prospective studies have reported associations between systemic inflammatory biomarkers and colorectal cancer (CRC) risk, but whether these reflect a causal role of inflammation or responses to preclinical disease remains uncertain. Methods: Using data from 383,850 UK Biobank participants (aged 4...

Heterologous engineering of receptors using OrthoRep (HERO) for directed evolution of GPCRs in yeast

Engineering G protein-coupled receptors (GPCRs) for biosensing applications remains challenging due to structural and functional constraints when such proteins are expressed in a heterologous host. OrthoRep offers the continuous accumulation and selection of signal-enhancing mutations in yeast, yet it has not been appl...

Composition confounding in the canonical ATL expression cohort: analysis code and results

Release v1.4 (2 October 2026) Adds the analyses cited in the Virology submission (Sections 2.2, 2.6, 2.8, 3.5 to 3.8). Earlier releases are unchanged. Every new script uses the project seed 20260817, prints its progress, takes its external inputs from the repository folder, and writes to results/. All six scripts were...

Reliability boundaries of protein language-model zero-shot variant scores: unified-score author-review research release

Reliability boundaries of protein language-model zero-shot variant scores: unified-score author-review research release Version: 2026.10.02-author-review. Scientific submission HOLD. Publication of this research artifact does not constitute journal submission, acceptance or independent scientific clearance. Scientific...

CropStabDB: a protein stability resource and Engineering Atlas of orthologue-supported substitutions for 30 plant proteomes

CropStabDB: a protein stability resource and Engineering Atlas of orthologue-supported substitutions for 30 plant proteomes Version 2.1.1. CropStabDB is a protein stability resource for 30 plant species - 29 crops and Arabidopsis thaliana, spanning 12 families and 1,425,716 proteins. Each protein carries a CropStab sco...

Ertapenem Exposure Is Associated with Downregulation of Purine Biosynthesis Proteins and Inhibition of Biofilm Formation in Staphylococcus aureus

This study demonstrates that ertapenem exhibits potent antibacterial activity against S. aureus and is a potential inhibitor of biofilm formation, and implicates a novel aspect of ertapenem’s activity connected to the disruption of purine biosynthesis in S. aureus through targeted downregulation of FGAM synthase.

Longitudinal monitoring of adalimumab levels and anti-adalimumab antibodies in Chinese patients with ankylosing spondylitis: a prospective cohort study

This study aimed to clarify the association between longitudinal adalimumab concentrations, anti-adalimumab antibodies (AAA) levels, and clinical response in Chinese patients with ankylosing spondylitis (AS). A prospective multi-center, observational cohort study of AS patients receiving adalimumab therapy w...

A coaxial electrospun bilayered membrane with bone morphogenetic Protein 2/gelatin core and γ-polyglutamic acid/β-tricalcium phosphate shell for alveolar bone regeneration.

An information-dynamics model of protein-templated DNA synthesis: From qualitative observations to quantitative predictions.

Protein-templated synthesis is thus an instance of information-field self-organization in which a fixed rule set in constraint space drives real-space data toward a unique stationary occupation distribution, a principle formally analogous to those previously validated in DNA sequencing by hybridization and RNA inverse...

Synonymous sequence design controls the folding, processing, and activity of the therapeutic protein ADAMTS13.

It is demonstrated that synonymous recoding can reshape proteostasis and activity, emphasizing the need for comprehensive evaluation of engineered therapeutic genes beyond yield.

Semi-synthesis of indole-fused taraxerone derivatives from Rhizophora stylosa Griff.: anti-bacterial study and docking insights.

A series of novel semisynthetic indole-fused taraxerone derivatives (2a-2f) were synthesised from taraxerone isolated from Rhizophora stylosa Griff. and characterised by 1H NMR,13C NMR, and HRMS analyses. Incorporation of the pharmacologically important indole moiety was aimed at enhancing protein-ligand interactions a...

KCTD1 p.Gly62Asp Variant in Scalp-Ear-Nipple Syndrome: Phenotypic and Structural Insights.

Pathogenic variants in the potassium channel tetramerization domain-containing 1 (KCTD1) gene cause scalp-ear-nipple syndrome (SENS), a rare autosomal dominant developmental disorder. Although the recurrent p.Gly62Asp variant has been previously reported, its genotype-phenotype correlation and structural pathogenic mec...